Immobilized Human Fc epsilon RI alpha, hFc Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Human IgE, His Tag with the EC50 of 2.5 ng/ml determined by ELISA. (QC Test)
Immobilized Human IgE, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Omalizumab, hFc Tag with the EC50 of 5.0 ng/ml determined by ELISA.

IgE Fc Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P01854-1.

Human

HEK293 Cells

Ser106-Lys428

> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of which are mediated through its two Fc receptors, FcεRI and CD23 (FcεRII). IgE and its interactions with these receptors are therefore potential targets for therapeutic intervention, and exciting progress has been made in this direction. Furthermore, recent structural studies of IgE-Fc, the two receptors, and of their complexes, have revealed a remarkable degree of plasticity at the IgE-CD23 interface and an even more remarkable degree of dynamic flexibility within the IgE molecule.