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PA2-GNU7

Name: PA2-GNU7
Brand: TargetMol
SKU: TP4024
Rating: 4.5 (1 reviews)

Catalog No. TP4024 Copy Product Info

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PA2-GNU7 is an antimicrobial peptide (AMP) with potent antibacterial activity, demonstrating minimum inhibitory concentrations (MIC) of 2 μM for Pseudomonas aeruginosa, 1 μM for Escherichia coli, 2 μM for Salmonella, 2 μM for Staphylococcus aureus, and 8 μM for Candida albicans. It rapidly and selectively kills Pseudomonas aeruginosa without affecting other symbiotic bacteria and significantly enhances the survival rate of mice infected with Pseudomonas aeruginosa. PA2-GNU7 has potential applications in researching and developing treatments for infections caused by multidrug-resistant Pseudomonas aeruginosa.

PA2-GNU7

Copy Product Info

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Catalog No. TP4024

PA2-GNU7

Cas No. 2387505-19-1

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	PA2-GNU7 is an antimicrobial peptide (AMP) with potent antibacterial activity, demonstrating minimum inhibitory concentrations (MIC) of 2 μM for Pseudomonas aeruginosa, 1 μM for Escherichia coli, 2 μM for Salmonella, 2 μM for Staphylococcus aureus, and 8 μM for Candida albicans. It rapidly and selectively kills Pseudomonas aeruginosa without affecting other symbiotic bacteria and significantly enhances the survival rate of mice infected with Pseudomonas aeruginosa. PA2-GNU7 has potential applications in researching and developing treatments for infections caused by multidrug-resistant Pseudomonas aeruginosa.
In vitro	PA2-GNU7 (21 h) demonstrates potent antibacterial activity, with minimum inhibitory concentrations (MIC) against Pseudomonas aeruginosa, Escherichia coli, Salmonella spp., Staphylococcus aureus, and Candida albicans at 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively. PA2-GNU7 (1 μM) selectively eradicates Pseudomonas aeruginosa in a dual-species culture (1:1 P. aeruginosa and E. coli or Salmonella).
In vivo	Administered intraperitoneally at a dose of PA2-GNU7 (15-25 mg/kg) 30 minutes post-infection, significantly enhances the survival rate of BALB/c mice infected with Pseudomonas aeruginosa.

Chemical Properties

Molecular Weight	3372.17
Formula	C₁₅₀H₂₇₆N₅₀O₃₇
Cas No.	2387505-19-1
Smiles	C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CC(C)C)=O)C)=O)C)=O)CCCCN)=O)CC(C)C)=O)[C@@H](C)O)=O)CO)=O)CCCCN)=O)=O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc