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Lophine
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Catalog No. T20509Cas No. 484-47-9
Alias NSC-62790, NSC62790, NSC 62790, 2,4,5-Triphenylimidazole
Lophine (NSC-62790) can be used in the synthesis of protein kinase inhibitors, calcium antagonists, strong Chemicalbook cardiac agents, and antitumor drugs. Lophine derivatives act as in vitro chemiluminescent activators for the detection of free radicals.
Lophine
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Purity: 99.95%
Catalog No. T20509Alias NSC-62790, NSC62790, NSC 62790, 2,4,5-TriphenylimidazoleCas No. 484-47-9
Lophine (NSC-62790) can be used in the synthesis of protein kinase inhibitors, calcium antagonists, strong Chemicalbook cardiac agents, and antitumor drugs. Lophine derivatives act as in vitro chemiluminescent activators for the detection of free radicals.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $29 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.95%
Appearance:Solid
Color:Yellow
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Product Introduction
Lophine AI Summary
Lophine inhibits Acyl coenzyme A:cholesterol acyltransferase 1 (ACAT) from rat liver with an IC50 value of 260.0 nM, indicating its potential to interfere with cholesterol esterification processes. It demonstrates antinociceptive activity in Swiss albino mice, as evidenced by increased latency times in the hot plate and tail flick tests over 120 minutes, suggesting pain-relieving properties. Additionally, the compound shows anti-inflammatory activity, reducing carrageenan-induced paw volume by 30.24% in Wistar rats after 3 hours. Although it exhibits little inhibition in NADPH oxidase 1 (NOX1) with an IC50 greater than 17000.0 nM, Lophine does show growth inhibition activity in various human tumor cell lines, with GI50 values ranging from around 18000 nM to 100000.0 nM. The compound demonstrates modest antioxidant activity (IC50 of 106050.0 nM) and minimal acetylcholinesterase (AChE) inhibition (16.08% at 10 µM) based on electric eel-derived AChE assays. It shows negligible activity in both beta-hematin formation inhibition and antimalarial assays against Plasmodium falciparum D6. Furthermore, the compound displays no significant inhibition of AChE or butyrylcholinesterase (BuChE) in other specific assay conditions, with IC50 values exceeding 10000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lophine (NSC-62790) can be used in the synthesis of protein kinase inhibitors, calcium antagonists, strong Chemicalbook cardiac agents, and antitumor drugs. Lophine derivatives act as in vitro chemiluminescent activators for the detection of free radicals. |
| Synonyms | NSC-62790, NSC62790, NSC 62790, 2,4,5-Triphenylimidazole |
| Molecular Weight | 296.37 |
| Formula | C21H16N2 |
| Cas No. | 484-47-9 |
| Smiles | c1ccc(cc1)-c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |
| Relative Density. | 1.0874 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (37.12 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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