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Eotaxin/CCL11 Protein, Human, Recombinant (His) V2 is expressed in E. coli. The accession number is P51671.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 μg | $61 | 7-10 days | 7-10 days | |
| 10 μg | $96 | 7-10 days | 7-10 days | |
| 20 μg | $157 | 7-10 days | 7-10 days | |
| 50 μg | $306 | 7-10 days | 7-10 days | |
| 100 μg | $535 | 7-10 days | 7-10 days | |
| 200 μg | $938 | 7-10 days | 7-10 days | |
| 500 μg | $1,990 | 7-10 days | 7-10 days | |
| 1 mg | $3,520 | 7-10 days | 7-10 days |
| Biological Activity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. |
| Description | Eotaxin/CCL11 Protein, Human, Recombinant (His) V2 is expressed in E. coli. The accession number is P51671. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-His |
| Accession Number | P51671 |
| Synonyms | SCYA11,chemokine (C-C motif) ligand 11 |
| Construction | Gly24-Pro97 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Molecular Weight | 9.46 kDa (Predicted). The protein migrates to 13-15 kDa (reducing conditions) |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in 20 mM PB, 500mM NaCl, 200 mM L-arginine (pH 7.4). |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| Research Background | The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders. |
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