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Taltobulin intermediate-4

Name: Taltobulin intermediate-4
Brand: TargetMol
SKU: T89648
Rating: 4.5 (1 reviews)

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Catalog No. T89648Cas No. 187345-37-5

Alias Taltobulin intermediate 4

Taltobulin intermediate-4 is a defined synthetic intermediate used in the multistep preparation of Taltobulin, a highly potent tubulin inhibitor and cytotoxic payload widely employed in antibody–drug conjugate development, where Taltobulin disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis in rapidly dividing tumor cells.

Taltobulin intermediate-4

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Catalog No. T89648Alias Taltobulin intermediate 4Cas No. 187345-37-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Taltobulin intermediate-4 is a defined synthetic intermediate used in the multistep preparation of Taltobulin, a highly potent tubulin inhibitor and cytotoxic payload widely employed in antibody–drug conjugate development, where Taltobulin disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis in rapidly dividing tumor cells.
Targets&IC50	KB 3-1 cells:2.5 nM
Synonyms	Taltobulin intermediate 4

Chemical Properties

Molecular Weight	412.56
Formula	C₂₂H₄₀N₂O₅
Cas No.	187345-37-5
Smiles	[C@H](C(N([C@H](/C=C(/C(OCC)=O)\C)C(C)C)C)=O)(NC(OC(C)(C)C)=O)[C@](C)(C)C

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (193.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4239 mL	12.1194 mL	24.2389 mL	121.1945 mL
5 mM	0.4848 mL	2.4239 mL	4.8478 mL	24.2389 mL
10 mM	0.2424 mL	1.2119 mL	2.4239 mL	12.1194 mL
20 mM	0.1212 mL	0.6060 mL	1.2119 mL	6.0597 mL
50 mM	0.0485 mL	0.2424 mL	0.4848 mL	2.4239 mL
100 mM	0.0242 mL	0.1212 mL	0.2424 mL	1.2119 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc