Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Taltobulin intermediate-4

Name: Taltobulin intermediate-4
Brand: TargetMol
SKU: T89648
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T89648Cas No. 187345-37-5

Alias Taltobulin intermediate 4

Taltobulin intermediate-4 is a defined synthetic intermediate used in the multistep preparation of Taltobulin, a highly potent tubulin inhibitor and cytotoxic payload widely employed in antibody–drug conjugate development, where Taltobulin disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis in rapidly dividing tumor cells.

Taltobulin intermediate-4

😃Good

Catalog No. T89648Alias Taltobulin intermediate 4Cas No. 187345-37-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Taltobulin intermediate-4 is a defined synthetic intermediate used in the multistep preparation of Taltobulin, a highly potent tubulin inhibitor and cytotoxic payload widely employed in antibody–drug conjugate development, where Taltobulin disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis in rapidly dividing tumor cells.
Targets&IC50	KB 3-1 cells:2.5 nM
Synonyms	Taltobulin intermediate 4

Chemical Properties

Molecular Weight	412.56
Formula	C₂₂H₄₀N₂O₅
Cas No.	187345-37-5
Smiles	[C@H](C(N([C@H](/C=C(/C(OCC)=O)\C)C(C)C)C)=O)(NC(OC(C)(C)C)=O)[C@](C)(C)C

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (193.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4239 mL	12.1194 mL	24.2389 mL	121.1945 mL
5 mM	0.4848 mL	2.4239 mL	4.8478 mL	24.2389 mL
10 mM	0.2424 mL	1.2119 mL	2.4239 mL	12.1194 mL
20 mM	0.1212 mL	0.6060 mL	1.2119 mL	6.0597 mL
50 mM	0.0485 mL	0.2424 mL	0.4848 mL	2.4239 mL
100 mM	0.0242 mL	0.1212 mL	0.2424 mL	1.2119 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc