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t-Butyl ester-PEG4-CH2COOH

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Catalog No. TYD-01894Cas No. 929087-83-2

t-Butyl ester-PEG4-CH2COOH is a PEG linker characterized by the presence of a tert-butyl group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of an activator (e.g., HATU) to form a stable amide bond. The hydrophilic PEG spacer improves solubility in aqueous media. The tert-butyl group can be deprotected under acidic conditions.

t-Butyl ester-PEG4-CH2COOH

t-Butyl ester-PEG4-CH2COOH

😃Good
Catalog No. TYD-01894Cas No. 929087-83-2
t-Butyl ester-PEG4-CH2COOH is a PEG linker characterized by the presence of a tert-butyl group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of an activator (e.g., HATU) to form a stable amide bond. The hydrophilic PEG spacer improves solubility in aqueous media. The tert-butyl group can be deprotected under acidic conditions.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
t-Butyl ester-PEG4-CH2COOH is a PEG linker characterized by the presence of a tert-butyl group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of an activator (e.g., HATU) to form a stable amide bond. The hydrophilic PEG spacer improves solubility in aqueous media. The tert-butyl group can be deprotected under acidic conditions.
Chemical Properties
Molecular Weight336.378
FormulaC15H28O8
Cas No.929087-83-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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