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Synonyms: ZTNFR-9, ZTNFR9, ZTNFR 9, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRICK-2, TRICK2, TRICK 2, TRAILR-2, TRAIL-R2, TRAILR2, TRAILR 2, TRAIL Receptor 2, TNFRSF10B, TNF-Related Apoptosis-Inducing Ligand Receptor 2, KILLER, DR-5, DR5, DR 5, Death Receptor 5, CD-262, CD262, CD 262


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $169 | 7-10 days | 7-10 days | |
| 20 µg | $267 | 7-10 days | 7-10 days | |
| 50 µg | $488 | 7-10 days | 7-10 days | |
| 100 µg | $776 | 7-10 days | 7-10 days | |
| 200 µg | $1,230 | 7-10 days | 7-10 days | |
| 500 µg | $2,290 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Biotinylated Cynomolgus TRAIL R2, His Tag at 0.5 μg/ml (100 μl/Well) on streptavidin (5 μg/ml) precoated plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.5 ng/ml determined by ELISA (QC Test). |
| Description | TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 Cells. The accession number is A0A2K5TXK0. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | A0A2K5TXK0 |
| Construction | Ile58-Ser212 |
| Protein Purity | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in PBS (pH 7.4). |
| Synonyms | ZTNFR-9, ZTNFR9, ZTNFR 9, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRICK-2, TRICK2, TRICK 2, TRAILR-2, TRAIL-R2, TRAILR2, TRAILR 2, TRAIL Receptor 2, TNFRSF10B, TNF-Related Apoptosis-Inducing Ligand Receptor 2, KILLER, DR-5, DR5, DR 5, Death Receptor 5, CD-262, CD262, CD 262 |
| Research Background | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| Molecular Weight | 18.28 kDa (Predicted); 30-38 kDa (Reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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