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COX-2-IN-55

🥰Excellent
Catalog No. T211247Cas No. 2649115-80-8

COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC). Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.

COX-2-IN-55

COX-2-IN-55

🥰Excellent
Catalog No. T211247Cas No. 2649115-80-8
COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC). Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.
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Product Introduction

Bioactivity
Description
COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC). Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.
In vitro
COX-2-IN-55 (compound 1) inhibits the viability of MDA-MB-231, MDA-MB-468, 4T1, T47D, and MCF-7 cells, with EC50 values of 14.99 μM, 14.26 μM, 11.23 μM, 17.3 μM, and 25.02 μM, respectively.
In vivo
COX-2-IN-55, administered at 25 mg/kg/day and 50 mg/kg/day orally for 28 days, exhibits significant antitumor activity in the MDA-MB-231 xenograft model using nu/nu nude mice, achieving up to 85% tumor regression. At a dosage of 100 mg/kg/day, COX-2-IN-55 does not cause notable biochemical or histological toxicity in mice after 48 days of treatment.
Chemical Properties
Molecular Weight486.51
FormulaC24H21F3N4O2S
Cas No.2649115-80-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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