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Pomalidomide-PEG3-C2-NH2 (TFA)

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Catalog No. T17882
Alias Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base), E3 ligase Ligand-Linker Conjugates 30 (TFA), Cereblon Ligand-Linker Conjugates 5 (TFA)

Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

Pomalidomide-PEG3-C2-NH2 (TFA)

Pomalidomide-PEG3-C2-NH2 (TFA)

😃Good
Catalog No. T17882Alias Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base), E3 ligase Ligand-Linker Conjugates 30 (TFA), Cereblon Ligand-Linker Conjugates 5 (TFA)
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
SynonymsPomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base), E3 ligase Ligand-Linker Conjugates 30 (TFA), Cereblon Ligand-Linker Conjugates 5 (TFA)
Chemical Properties
Molecular Weight562.49
FormulaC23H29F3N4O9
SmilesO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN)=O.OC(C(F)(F)F)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 16.67 mg/mL (29.64 mM), Sonication is recommended.
DMSO: 100 mg/mL (177.78 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.7778 mL8.8890 mL17.7781 mL88.8905 mL
5 mM0.3556 mL1.7778 mL3.5556 mL17.7781 mL
10 mM0.1778 mL0.8889 mL1.7778 mL8.8890 mL
20 mM0.0889 mL0.4445 mL0.8889 mL4.4445 mL
DMSO
1mg5mg10mg50mg
50 mM0.0356 mL0.1778 mL0.3556 mL1.7778 mL
100 mM0.0178 mL0.0889 mL0.1778 mL0.8889 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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