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PDGFRα kinase-IN-2

🥰Excellent
Catalog No. T212468Cas No. 3066103-58-7

PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.

PDGFRα kinase-IN-2

PDGFRα kinase-IN-2

🥰Excellent
Catalog No. T212468Cas No. 3066103-58-7
PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.
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Product Introduction

Bioactivity
Description
PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.
Targets&IC50
PDGFRα:2.1 nM
In vivo
PDGFRα kinase-IN-2 (Compound 6o) (0.1-10 μM, 72 h) significantly hinders the formation of zebrafish intersegmental vessels (ISV) in a dose-dependent manner and demonstrates superior anti-angiogenic activity compared to Sorafenib. Enpp-1-IN-27 (0.1-50 μM, 24 h) exhibits a particularly low lethality rate in zebrafish embryos and has a weaker effect than Sorafenib.
Chemical Properties
Molecular Weight429.47
FormulaC24H23N5O3
Cas No.3066103-58-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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