IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated V2

Catalog No. TMPY-05648U

IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated V2 is expressed in HEK293 Cells. The accession number is Q9NPF7(IL-23 alpha)&P29460(IL-12 beta).

IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated V2

Catalog No. TMPY-05648U

IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated V2 is expressed in HEK293 Cells. The accession number is Q9NPF7(IL-23 alpha)&P29460(IL-12 beta).

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Product Information

Biological Activity	Immobilized Human IL-23R, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.87 μg/ml determined by ELISA.
Description	IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated V2 is expressed in HEK293 Cells. The accession number is Q9NPF7(IL-23 alpha)&P29460(IL-12 beta).
Species	Human
Expression System	HEK293 Cells
Tag	C-His-Avi
Accession Number	Q9NPF7(IL-23 alpha)&P29460(IL-12 beta)
Synonyms	SGRF,P19,IL23P19,IL-23A,IL-23,IL23
Construction	Arg20-Pro189(IL-23 alpha) & Ile23-Ser328(IL-12 beta)
Protein Purity	> 95% as determined by Tris-Bis PAGE
Molecular Weight	21.7 (IL-23 alpha) & 34.7 (IL-12 beta) kDa (Predicted); 24 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) kDa (Due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.