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DHQ

Name: DHQ
Brand: TargetMol
SKU: T20436
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20436Cas No. 15804-19-0

Alias 2,3-dihydroxy-quinoxalin

DHQ (2,3-dihydroxy-quinoxalin) is an inducer of ATPase activity that of Herpes Simplex Virus thymidine kinase.

DHQ

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Purity: 99.89%

Catalog No. T20436Alias 2,3-dihydroxy-quinoxalinCas No. 15804-19-0

DHQ (2,3-dihydroxy-quinoxalin) is an inducer of ATPase activity that of Herpes Simplex Virus thymidine kinase.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$41	In Stock	In Stock
500 mg	$110	In Stock	In Stock
1 g	$159	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

DHQ AI Summary

DHQ demonstrates a diverse range of bioactivities across several targets. It inhibits the binding of [3H]DCKA to the NMDA receptor in rat brain membranes with an IC50 value of 9800.0 nM and also inhibits [3H]glycine binding at the NMDA receptor glycine site, with various IC50 values reported (up to 39000.0 nM). It exhibits a binding affinity with a Kb value of 16500.0 nM towards the glycine site of the NMDA receptor and a significantly lower affinity towards other glutamate receptors. Additionally, DHQ shows inhibition of [3H]AMPA binding to AMPA receptors with low affinity (Ki > 100,000.0 nM), suggesting minimal effect on AMPA receptor activity. Apart from its activity on NMDA and AMPA receptors, the compound also shows inhibition of Human Jumonji Domain Containing 2E (JMJD2E) and the malarial parasite plastid, with respective potencies of 25118.9 nM and 10417.9 nM. It acts as an agonist of the mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome with a potency of 5011.9 nM and exhibits dose-dependent inhibition of TPA-induced Epstein-Barr virus early antigen activation in human Raji cells while also displaying cytotoxicity at higher concentrations. Additionally, 27688 inhibits D-amino acid oxidase in porcine kidney homogenate (IC50: 33600.0 nM) and activates Trypanosoma cruzi cruzain. It shows an inhibitory effect on Cryptosporidium hominis TS-DHFR and on HIV-1 subtype B reverse transcriptase, albeit with low inhibition percentages at higher concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DHQ (2,3-dihydroxy-quinoxalin) is an inducer of ATPase activity that of Herpes Simplex Virus thymidine kinase.
Synonyms	2,3-dihydroxy-quinoxalin

Chemical Properties

Molecular Weight	162.15
Formula	C₈H₆N₂O₂
Cas No.	15804-19-0
Smiles	OC1=NC2=CC=CC=C2N=C1O
Relative Density.	1.336g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (370.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1671 mL	30.8356 mL	61.6713 mL	308.3565 mL
5 mM	1.2334 mL	6.1671 mL	12.3343 mL	61.6713 mL
10 mM	0.6167 mL	3.0836 mL	6.1671 mL	30.8356 mL
20 mM	0.3084 mL	1.5418 mL	3.0836 mL	15.4178 mL
50 mM	0.1233 mL	0.6167 mL	1.2334 mL	6.1671 mL
100 mM	0.0617 mL	0.3084 mL	0.6167 mL	3.0836 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DHQATPase

DHQ

DHQ

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