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DBI-2
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Catalog No. T88234Cas No. 2939087-00-8
DBI-2, an AMPK activator targeting mitochondrial complex I, disrupts the OXPHOS process and reduces ATP production in mitochondria. Additionally, DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells.
DBI-2
😃Good
Catalog No. T88234Cas No. 2939087-00-8
DBI-2, an AMPK activator targeting mitochondrial complex I, disrupts the OXPHOS process and reduces ATP production in mitochondria. Additionally, DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 4-6 weeks | 4-6 weeks | |
| 50 mg | $1,980 | 4-6 weeks | 4-6 weeks | |
| 100 mg | $2,500 | 4-6 weeks | 4-6 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | DBI-2, an AMPK activator targeting mitochondrial complex I, disrupts the OXPHOS process and reduces ATP production in mitochondria. Additionally, DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells. |
| In vitro | DBI-2 inhibits the proliferation of LS174T and HCT116 cells with IC 50 values of 1.14 μM and 0.53 μM, respectively [1]. At a concentration of 3 μM for 24 hours, DBI-2 induces growth inhibition by activating AMPK and suppressing the mTOR and Wnt pathways [1]. |
| In vivo | DBI-2 (40 mg/kg; intraperitoneal injection; for 12 days) effectively inhibits tumor growth in a colorectal cancer (CRC) xenograft mouse model [1]. Animal Model: RAG1 −/− γc − mice injected with S174T cells [1] Dosage: 40 mg/kg Administration: Intraperitoneal administration; for 12 days Result: Suppressed tumor growth. |
| Molecular Weight | 473.40 |
| Formula | C24H29BrN2O3 |
| Cas No. | 2939087-00-8 |
| Smiles | O=C1C(=COC2=CC(OCCCCN(C)CCN(C)C)=CC=C21)C=3C=CC(Br)=CC3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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