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PROTAC sEH degrader-2
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Catalog No. T210664
PROTACsEH degrader-2 is a PROTAC degrader that targets soluble epoxide hydrolase (sEH), with pIC50 values of 8.37 (human sEH-H) and 7.12 (mouse sEH-H). It is applicable for research into inflammation and neuroinflammation-related diseases, such as Alzheimer's disease.
PROTAC sEH degrader-2
PROTAC sEH degrader-2
😃Good
Catalog No. T210664
PROTACsEH degrader-2 is a PROTAC degrader that targets soluble epoxide hydrolase (sEH), with pIC50 values of 8.37 (human sEH-H) and 7.12 (mouse sEH-H). It is applicable for research into inflammation and neuroinflammation-related diseases, such as Alzheimer's disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTACsEH degrader-2 is a PROTAC degrader that targets soluble epoxide hydrolase (sEH), with pIC50 values of 8.37 (human sEH-H) and 7.12 (mouse sEH-H). It is applicable for research into inflammation and neuroinflammation-related diseases, such as Alzheimer's disease. |
| In vitro | PROTAC sEH degrader-2 (Compound 23) demonstrates significant nanomolar range degradation potency against hsEH-H, reaching a maximum degradation rate (Dmax) of 75% within 18 hours at concentrations of 0.3-10 μM over 1-24 hours. This compound shows no marked toxicity in HepG2 cells at 0.5-50 μM after 72 hours. Additionally, PROTAC sEH degrader-2 (300 nM) induces sEH degradation in human primary M1 macrophages, murine primary hepatocytes, and human ex vivo lung tissue slices. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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