Shopping Cart

Your shopping cart is currently empty

Coniine hydrochloride

Name: Coniine hydrochloride
Brand: TargetMol
SKU: TN3695
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. TN3695Cas No. 15991-59-0

Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.

Coniine hydrochloride

😃Good

Purity: 99.86%

Catalog No. TN3695Cas No. 15991-59-0

Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$146	In Stock	In Stock
50 mg	$232	In Stock	In Stock
100 mg	$365	In Stock	In Stock
200 mg	$503	-	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.
In vitro	Reduction of γ-coniceine to coniine is facilitated by NADPH-dependent γ-coniceine reductase.?Although coniine is notorious for its toxicity, there is no consensus on its ecological roles, especially in the carnivorous pitcher plants where it occurs.?Lately there has been renewed interest in coniine's medical uses particularly for pain relief without an addictive side effect.

Chemical Properties

Molecular Weight	163.70
Formula	C₈H₁₈ClN
Cas No.	15991-59-0
Smiles	Cl.CCCC1CCCCN1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.50 mg/mL (167.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1087 mL	30.5437 mL	61.0874 mL	305.4368 mL
5 mM	1.2217 mL	6.1087 mL	12.2175 mL	61.0874 mL
10 mM	0.6109 mL	3.0544 mL	6.1087 mL	30.5437 mL
20 mM	0.3054 mL	1.5272 mL	3.0544 mL	15.2718 mL
50 mM	0.1222 mL	0.6109 mL	1.2217 mL	6.1087 mL
100 mM	0.0611 mL	0.3054 mL	0.6109 mL	3.0544 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc