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SARS-CoV-2 Papain-Like Protease Protein
(Synonyms: Replicase polyprotein 1a, pp1a, PL-PRO, PLpro, Papain-like Protease) Copy Product InfoSynonyms: Replicase polyprotein 1a, pp1a, PL-PRO, PLpro, Papain-like Protease
Catalog No. TMPJ-01431 Copy Product Info
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $112 | 7-10 days | 7-10 days | |
| 10 μg | $183 | 7-10 days | 7-10 days | |
| 20 μg | $295 | 7-10 days | 7-10 days | |
| 50 μg | $558 | 7-10 days | 7-10 days | |
| 100 μg | $919 | 7-10 days | 7-10 days | |
| 200 μg | $1,520 | 7-10 days | 7-10 days | |
| 500 μg | $2,970 | 7-10 days | 7-10 days | |
| 1 mg | $4,480 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons. |
| Species | SARS-CoV-2 |
| Expression System | E. coli |
| Tag | Tag Free |
| Accession Number | QHD43415.1 |
| Amino Acid | Glu1564-Lys1878 |
| Construction | Glu1564-Lys1878 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 10 mM 2-Mercaptoethanol, 20% Glycerol, pH 7.5. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | Replicase polyprotein 1a, pp1a, PL-PRO, PLpro, Papain-like Protease |
| Research Background |
| Molecular Weight | 34 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: SARS-CoV-2 Papain-Like Protease Protein chemical structure | SARS-CoV-2 Papain-Like Protease Protein molecular weight
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