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  • Inhibitors & Agonists
    7571
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
MHY1485
T1908326914-06-1
MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, leading to accumulation of LC3II proteins and increased autophagosomes, thereby inhibiting cellular autophagy.
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TargetMol | Inhibitor Hot
PND-1186
VS-4718, SR-2516, PND1186, PND 1186
T19501061353-68-1
PND-1186 (VS-4718) is a specific and reversible FAK inhibitor with an IC50 of 1.5 nM.
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TargetMol | Inhibitor Hot
Enzalutamide
MDV3100
T6002915087-33-1
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP) that activates autophagy, exhibits antitumor activity, and is commonly used in treating desmoplasia-resistant prostate cancer.
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TargetMol | Inhibitor Hot
Ferrostatin-1
Ferrostatin-1 (Fer-1), Ferrostatin 1
T6500347174-05-4
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and antifungal activities.
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TargetMol | Inhibitor Hot
voxelotor
GBT 440
T75811446321-46-5
Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).
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TargetMol | Inhibitor Hot
Imiquimod
S-26308, R 837, IMQ
T013499011-02-6
Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.
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Hexylresorcinol
4-Hexylresorcinol
T0314136-77-6
Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene utilized topically as an antiseptic for minor skin infection treatment.
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Erlotinib
R1415, OSI-744, NSC 718781, CP358774
T0373183321-74-6
Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.
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Adenosine
D-Adenosine, Adenine riboside
T085358-61-7
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
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Erythromycin
E-Mycin
T1032114-07-8
Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.
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Olanzapine
LY170053
T1567132539-06-1
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
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Sulfentrazone
FP-846
T21164122836-35-5
Sulfentrazone (FP-846) is purified form of sulfentrazone which acts as a protoporphyrinogen oxidase inhibitor.It is a phenyl triazolinone herbicide
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Cladribine
CldAdo, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, 2CdA
T25584291-63-8
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
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Spermidine
N-(4-Aminobutyl)-1,3-diaminopropane, N-(3-Aminopropyl)-1,4-diaminobutane
T4893124-20-9
Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.
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Heptadecanoic acid
T4903506-12-7
Heptadecanoic acid is a fatty acid of exogenous (primarily ruminant) origin. Many odd length long chain amino acids are derived from the consumption of dairy fats (milk and meat). Heptadecanoic acid constitutes 0.61% of milk fat and 0.83% of ruminant me
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Spermidine trihydrochloride
Spermidine hydrochloride, 4-Azaoctamethylenediamine trihydrochloride
T5080334-50-9
Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
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HEPES
T85497365-45-9
HEPES is a zwitterionic sulfonic acid buffering agent, commonly used to uphold a neutral pH of basal medium within cell cultures.HEPES is a potent inducer of lysosome biogenesis.
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Quinizarin
1,4-Dihydroxyanthraquinone
TN213281-64-1
Quinizarin (1,4-Dihydroxyanthraquinone) is a natural product
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Epirubicin hydrochloride
Pharmorubicin, Epirubicin HCl, 4'-Epidoxorubicin hydrochloride, 4'-epidoxorubicin HCl
T012556390-09-1
Epirubicin hydrochloride (Pharmorubicin) is an adriamycin derivative, a topoisomerase (Topo) inhibitor, and a Forkhead box protein p3 (Foxp3) inhibitor. Epirubicin hydrochloride has antitumor activity.
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Digitonin
T272111024-24-1
Digitonin is a natural product of the glycoside family and is a detergent. Digitonin has antitumor activity, binds to cholesterol molecules to increase the permeability of cell membranes, and is active in the cleavage of cell membranes in a wide range of cells.
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OTS514
OTS514 Hydrochloride, OTS514 HCl, OTS-514, OTS 514
T4134L1338540-63-8
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
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1-2 weeks
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Butein
2',3,4,4'-tetrahydroxy Chalcone
T6427487-52-5
Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator. It sensitizes HeLa cells to Cisplatin by targeting FoxO3a via the AKT and ERK p38 MAPK pathways.
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Embelin
NSC 91874, Emberine, Embelic acid
T6485550-24-3
Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
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telaglenastat
CB-839, CB839, CB 839
T67971439399-58-2
Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.
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