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HRX-0233
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Catalog No. T200053Cas No. 2409140-12-9
Alias HRX0233, HRX 0233
HRX-0233 is a small-molecule MAP2K4 inhibitor that induces strong tumor regression without apparent toxicity in KRASG12C-mutant non-small cell lung cancer models, prevents receptor tyrosine kinase feedback activation during sotorasib monotherapy. HRX-0233 achieves sustained MAPK pathway suppression, supporting its application in lung, colon, and AR-negative prostate cancer research.
HRX-0233
😃Good
Purity: 99.59%
Catalog No. T200053Alias HRX0233, HRX 0233Cas No. 2409140-12-9
HRX-0233 is a small-molecule MAP2K4 inhibitor that induces strong tumor regression without apparent toxicity in KRASG12C-mutant non-small cell lung cancer models, prevents receptor tyrosine kinase feedback activation during sotorasib monotherapy. HRX-0233 achieves sustained MAPK pathway suppression, supporting its application in lung, colon, and AR-negative prostate cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $117 | - | In Stock | |
| 5 mg | $289 | - | In Stock | |
| 10 mg | $469 | - | In Stock | |
| 25 mg | $953 | - | In Stock | |
| 50 mg | $1,520 | - | In Stock | |
| 100 mg | $2,430 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.59%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HRX-0233 is a small-molecule MAP2K4 inhibitor that induces strong tumor regression without apparent toxicity in KRASG12C-mutant non-small cell lung cancer models, prevents receptor tyrosine kinase feedback activation during sotorasib monotherapy. HRX-0233 achieves sustained MAPK pathway suppression, supporting its application in lung, colon, and AR-negative prostate cancer research. |
| In vivo | In preclinical patient-derived xenograft (PDX) and cell line xenograft models of KRAS-mutant cancer, the combination of HRX-0233 with RAS inhibitors resulted in enhanced tumor regression compared to monotherapy [1][2]. |
| Synonyms | HRX0233, HRX 0233 |
| Molecular Weight | 497.52 |
| Formula | C24H21F2N5O3S |
| Cas No. | 2409140-12-9 |
| Smiles | O=C(C1=CC=C(F)C(NS(=O)(=O)CCC)=C1F)C2=CNC3=NC=C(C=C32)C=4C=NC(=NC4)C5CC5 |
| Color | White |
| Appearance | Solid |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 13 mg/mL (26.13 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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