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MDL-800

Catalog No. T64529 CAS 2275619-53-7

Synonyms: MDL 800, MDL800

MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.

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MDL-800, CAS 2275619-53-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 120.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 301.00
50 mg	In stock	$ 451.00
100 mg	In stock	$ 663.00
500 mg	In stock	$ 1,390.00

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Purity: 100%

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Description	MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
In vitro	MDL-800 increased SIRT6 deacetylase activity with an EC50 value of 11.0 ± 0.3 μM; MDL-800 (10-50 μM) induced dose-dependent deacetylation of histone H3 in 12 NSCLC cell lines. Treatment with MDL-800 dose dependently inhibited the proliferation of 12 NSCLC cell lines with IC50 values ranging from 21.5 to 34.5 μM. The antiproliferation effect of MDL-800 was significantly diminished by SIRT6 knockout. Treatment with MDL-800 induced remarkable cell cycle arrest at the G0/G1 phase in NSCLC HCC827 and PC9 cells. Furthermore, MDL-800 (25, 50 μM) enhanced the antiproliferation of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in osimertinib-resistant HCC827 and PC9 cells as well as in patient-derived primary tumor cells, and suppressed mitogen-activated protein kinase (MAPK) pathway.[1]
In vivo	In HCC827 cell-derived xenograft nude mice, intraperitoneal administration of MDL-800 (80 mg · kg-1 · d-1, for 14 days) markedly suppressed the tumor growth, accompanied by enhanced SIRT6-dependent histone H3 deacetylation and decreased p-MEK and p-ERK in tumor tissues.[1]

Synonyms	MDL 800, MDL800
Molecular Weight	626.3
Formula	C21H16BrCl2FN2O6S2
CAS No.	2275619-53-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.63 mg/mL (100 mM), Sonication is recommended.

References and Literature

1. Shang JL, et al. MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacol Sin. 2021 Jan;42(1):120-131. 2. Jiang X, et al. MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-κB Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice. Oxid Med Cell Longev. 2022 Apr 27;2022:1619651.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Bioactive Compounds Library Max Histone Modification Compound Library Anti-Cancer Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

SIRT5 inhibitor 1 WAY-323061 SRT1720 hydrochloride E1231 YM-08 SIRT2-IN-9 5-Feruloylquinic acid SRT 2104

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Keywords

MDL-800 2275619-53-7 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin MDL 800 MDL800 inhibitor inhibit

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