Shopping Cart

Remove All
Your shopping cart is currently empty

KRM-III

Name: KRM-III
Brand: TargetMol
SKU: T35885
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T35885Cas No. 79220-94-3

KRM-III is an orally active T cell antigen receptor (TCR) inhibitor with anti-inflammatory activity that potently inhibits TCR and myristate acetate/fosfomycin/ionomycin-induced NFAT nuclear factor activation and T cell proliferation, with an IC50 of approximately 5 μM.

KRM-III

🥰Excellent

Purity: 99.25%

Catalog No. T35885Cas No. 79220-94-3

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$51	In Stock
10 mg	$81	In Stock
25 mg	$173	In Stock
50 mg	$258	In Stock
100 mg	$368	In Stock
200 mg	$506	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.25%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	KRM-III is an orally active T cell antigen receptor (TCR) inhibitor with anti-inflammatory activity that potently inhibits TCR and myristate acetate/fosfomycin/ionomycin-induced NFAT nuclear factor activation and T cell proliferation, with an IC50 of approximately 5 μM.
Targets&IC50	Proliferation (T-cells):~5 μM

Chemical Properties

Molecular Weight	252.33
Formula	C₁₅H₁₂N₂S
Cas No.	79220-94-3
Smiles	S=c1[nH]c(cn1-c1ccccc1)-c1ccccc1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25.23 mg/mL (100 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9631 mL	19.8153 mL	39.6306 mL	198.1532 mL
5 mM	0.7926 mL	3.9631 mL	7.9261 mL	39.6306 mL
10 mM	0.3963 mL	1.9815 mL	3.9631 mL	19.8153 mL
20 mM	0.1982 mL	0.9908 mL	1.9815 mL	9.9077 mL
50 mM	0.0793 mL	0.3963 mL	0.7926 mL	3.9631 mL
100 mM	0.0396 mL	0.1982 mL	0.3963 mL	1.9815 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc