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Catestatin

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Catalog No. TP2058Cas No. 142211-96-9

Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.

Catestatin
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Catestatin

😃Good
Catalog No. TP2058Cas No. 142211-96-9
Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$754-6 weeks4-6 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
Chemical Properties
Molecular Weight2425.84
FormulaC107H173N37O26S
Cas No.142211-96-9
SmilesC(CNC([C@@H](NC([C@H](CC1=CC=CC=C1)NC(CNC([C@H](CC2=CC=C(O)C=C2)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CO)=O)CCSC)=O)CCCNC(=N)N)=O)CC(C)C)=O)CO)=O)=O)CCCNC(=N)N)=O)C)=O)CCCNC(=N)N)=O)=O)=O)=O)=O)CCCNC(=N)N)=O)(=O)N4[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)=O)CCC4
Relative Density.1.47 g/cm3 (Predicted)
SequenceArg-Ser-Met-Arg-Leu-Ser-Phe-Arg-Ala-Arg-Gly-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Leu-Gln-Leu
Sequence ShortRSMRLSFRARGYGFRGPGLQL
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1 mg/mL (0.41 mM)

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