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tPA Protein, Mouse, Recombinant (His)

Catalog No. TMPK-00810
Synonyms: PLAT, Reteplase, t-PA, tPA, Alteplase

Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.

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tPA Protein, Mouse, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg 5 days $ 465.00
500 μg 5 days $ 1,850.00
1 mg 5 days $ 3,100.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.
Species Mouse
Expression System HEK293
Tag C-His
Accession Number P11214
Synonyms PLAT, Reteplase, t-PA, tPA, Alteplase
Construction Recombinant Mouse tPA Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ser33-Gln559, which consists of two chains: chain A (Ser33-Arg308) and chain B (Ile309-Gln559).[Accession |P11214]
Protein Purity > 95% as determined by Tris-Bis PAGE
Molecular Weight The protein has a predicted MW of 60.57 kDa. It migrates to 13-15 kDa (chain A and chain B fragment), 30-34 kDa and 35-40 kDa based on Tris-Bis PAGE result.
Endotoxin Less than 1EU per μg by the LAL method.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage

-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.

References and Literature

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Keywords

tPA Protein, Mouse, Recombinant (His) PLAT Reteplase t-PA tPA Alteplase recombinant recombinant-proteins proteins protein

 

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