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Eclazolast

Name: Eclazolast
Brand: TargetMol
SKU: T25360
Price: 120 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25360Cas No. 80263-73-6

Alias RHC-2871, RHC2871, RHC 2871, REV2871, REV 2871

Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell.

Eclazolast

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Purity: 98.61%

Catalog No. T25360Alias RHC-2871, RHC2871, RHC 2871, REV2871, REV 2871Cas No. 80263-73-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$120	In Stock	In Stock
5 mg	$290	In Stock	In Stock
10 mg	$440	In Stock	In Stock
25 mg	$728	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,390	In Stock	In Stock
500 mg	$2,770	-	In Stock
1 mL x 10 mM (in DMSO)	$276	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.61%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell.
Targets&IC50	Rat:12 mg/kg(ED50), AIR:800 microM
In vitro	Eclazolast down-regulates IP3 levels. In contrast to lipophilic drugs, eclazolast does not affect artificial bilayers and erythrocyte membranes, and there is no effect on thapsigargin-induced Ca2+ influx. The effect of eclazolast was highly dependent on the antigen concentration with which the cells were triggered.[1]
In vivo	REV 2871 (CHBZ) was shown to be potent and orally effective inhibitors of passive cutaneous anaphylaxis (PCA) in the rat (ED50 = 12 mg/kg). In the guinea pig lung slice model, CHBZ inhibited AIR (IC50 = 800 microM).[2]
Synonyms	RHC-2871, RHC2871, RHC 2871, REV2871, REV 2871

Chemical Properties

Molecular Weight	269.68
Formula	C₁₂H₁₂ClNO₄
Cas No.	80263-73-6
Smiles	C(OCCOCC)(=O)C=1OC=2C(N1)=CC(Cl)=CC2
Relative Density.	1.313g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (101.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7081 mL	18.5405 mL	37.0810 mL	185.4049 mL
5 mM	0.7416 mL	3.7081 mL	7.4162 mL	37.0810 mL
10 mM	0.3708 mL	1.8540 mL	3.7081 mL	18.5405 mL
20 mM	0.1854 mL	0.9270 mL	1.8540 mL	9.2702 mL
50 mM	0.0742 mL	0.3708 mL	0.7416 mL	3.7081 mL
100 mM	0.0371 mL	0.1854 mL	0.3708 mL	1.8540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc