IL-5 Protein, Mouse, Recombinant (HEK293, His)

Catalog No. TMPY-02554U

IL-5 Protein, Mouse, Recombinant (HEK293, His) is expressed in HEK293 Cells. The accession number is P04401.

IL-5 Protein, Mouse, Recombinant (HEK293, His)

Catalog No. TMPY-02554U

IL-5 Protein, Mouse, Recombinant (HEK293, His) is expressed in HEK293 Cells. The accession number is P04401.

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Product Information

Biological Activity	Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells.The ED50 for this effect is 115.5 pg/mL.
Description	IL-5 Protein, Mouse, Recombinant (HEK293, His) is expressed in HEK293 Cells. The accession number is P04401.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	P04401
Synonyms	Il-5
Construction	Met21-Gly133
Protein Purity	> 95% as determined by SDS-PAGE
Molecular Weight	13.9 kDa (Predicted); 14-26 kDa (Reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functions on eosinophils. These include the down modulation of Mac-1,the upregulation of receptors for IgA and IgG,the stimulation of lipid mediator (leukotriene C4 and PAF) secretion and the induction of granule release.IL-5 also promotes the growth and differentiation of eosinophils.