PF-06733804

Name: PF-06733804
Brand: TargetMol
SKU: T13207
Rating: 4.5 (1 reviews)

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Catalog No. T13207Cas No. 1873373-33-1

PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.

PF-06733804

😃Good

Catalog No. T13207Cas No. 1873373-33-1

PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.

Pack Size	Price	Availability
25 mg	$1,820	8-10 weeks
50 mg	$2,380	8-10 weeks
100 mg	$3,100	8-10 weeks

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Product Introduction

Bioactivity

Description	PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
Targets&IC50	TrkC:2.2 nM (in cell-based assays), TrkB:6.2 nM (in cell-based assays), TrkA:8.4 nM
In vitro	In the FP and PX assay, PF-06733804 inhibits hERG with IC50s of 79 μM and 88 μM, respectively.

Chemical Properties

Molecular Weight	474.38
Formula	C₂₀H₁₉F₅N₄O₄
Cas No.	1873373-33-1
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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