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XMD-17-51

Name: XMD-17-51
Brand: TargetMol
SKU: T22460
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22460Cas No. 1628614-50-5

Alias XMD17-51

XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.

XMD-17-51

🥰Excellent

Purity: 99.04%

Catalog No. T22460Alias XMD17-51Cas No. 1628614-50-5

XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$293	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.04%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.
In vitro	Overexpression of DCLK1 was found to reduce the antiproliferative effect of XMD-17-51 in the A549 cell line, increasing its IC50 from 27.575 µM to 53.197 µM and vice versa. In a cell-free assay, XMD-17-51 showed an inhibitory effect on DCLK1 kinase activity with an IC50 of 14.64 nM. In non-small cell lung cancer (NSCLC) cell lines, XMD-17-51 also reduced DCLK1 protein expression, which resulted in inhibition of cell proliferation, epithelial-mesenchymal transition (EMT), and stem cell characterization. [1]
Synonyms	XMD17-51

Chemical Properties

Molecular Weight	404.47
Formula	C₂₁H₂₄N₈O
Cas No.	1628614-50-5
Smiles	O=C1C=2C=CC=CC2N(C3=NC(=NC=C3N1C)NC=4C=NN(C4)C5CCNCC5)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40.00 mg/mL (98.89 mM), Sonication is recommended.

DMSO: 40.00 mg/mL (98.89 mM), Sonication is recommended.

H2O: 1.00 mg/mL (2.47 mM), Sonication is recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4724 mL	12.3619 mL	24.7237 mL	123.6186 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4945 mL	2.4724 mL	4.9447 mL	24.7237 mL
10 mM	0.2472 mL	1.2362 mL	2.4724 mL	12.3619 mL
20 mM	0.1236 mL	0.6181 mL	1.2362 mL	6.1809 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL	2.4724 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc