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XMD-17-51 (Synonyms: XMD17-51)

Name: XMD-17-51
Brand: TargetMol
SKU: T22460
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T22460 Copy Product Info

Purity: 99.04%

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XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.

XMD-17-51

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Catalog No. T22460

Synonyms XMD17-51

XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.

Cas No. 1628614-50-5

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$293	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.04%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.
In vitro	Overexpression of DCLK1 was found to reduce the antiproliferative effect of XMD-17-51 in the A549 cell line, increasing its IC50 from 27.575 µM to 53.197 µM and vice versa. In a cell-free assay, XMD-17-51 showed an inhibitory effect on DCLK1 kinase activity with an IC50 of 14.64 nM. In non-small cell lung cancer (NSCLC) cell lines, XMD-17-51 also reduced DCLK1 protein expression, which resulted in inhibition of cell proliferation, epithelial-mesenchymal transition (EMT), and stem cell characterization. [1]
Synonyms	XMD17-51

Chemical Properties

Molecular Weight	404.47
Formula	C₂₁H₂₄N₈O
Cas No.	1628614-50-5
Smiles	O=C1C=2C=CC=CC2N(C3=NC(=NC=C3N1C)NC=4C=NN(C4)C5CCNCC5)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (98.89 mM), Sonication is recommended.

DMSO: 40 mg/mL (98.89 mM), Sonication is recommended.

H2O: 1 mg/mL (2.47 mM), Sonication is recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4724 mL	12.3619 mL	24.7237 mL	123.6186 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4945 mL	2.4724 mL	4.9447 mL	24.7237 mL
10 mM	0.2472 mL	1.2362 mL	2.4724 mL	12.3619 mL
20 mM	0.1236 mL	0.6181 mL	1.2362 mL	6.1809 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL	2.4724 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc