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MK-0626 free base
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Catalog No. T68863Cas No. 690257-74-0
Alias MK0626
MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor that attenuates hepatic steatosis and accumulation by enhancing AMPK activity.MK-0626 attenuates TAC-induced diabetic pancreatic islet injury by restoring the expression of GLP-1R.MK-0626 is able to increase circulating endothelial progenitor cell numbers and endothelial-type nitric oxide synthase expression by promoting neoangiogenesis.
MK-0626 free base
🥰Excellent
Purity: 100%
Catalog No. T68863Alias MK0626Cas No. 690257-74-0
MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor that attenuates hepatic steatosis and accumulation by enhancing AMPK activity.MK-0626 attenuates TAC-induced diabetic pancreatic islet injury by restoring the expression of GLP-1R.MK-0626 is able to increase circulating endothelial progenitor cell numbers and endothelial-type nitric oxide synthase expression by promoting neoangiogenesis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $3,970 | In Stock | |
| 50 mg | $5,550 | In Stock | |
| 100 mg | $7,490 | In Stock |
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Purity:100%
ee:99.7%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor that attenuates hepatic steatosis and accumulation by enhancing AMPK activity.MK-0626 attenuates TAC-induced diabetic pancreatic islet injury by restoring the expression of GLP-1R.MK-0626 is able to increase circulating endothelial progenitor cell numbers and endothelial-type nitric oxide synthase expression by promoting neoangiogenesis. |
| In vivo | Methods: ob/ob mice were treated with MK-0626 (1.5 and 3 mg/kg, oral), blood samples were collected, and total hepatectomy was performed. Results: MK-0626 treatment increased the mRNA expression of peroxisome proliferator-activated receptor α/microsomal triglyceride transfer protein, but decreased the mRNA expression of sterol regulatory element binding transcription factor-1c/fatty acid synthase/stearoyl-CoA desaturase-1. [1] |
| Alias | MK0626 |
| Molecular Weight | 442.46 |
| Formula | C22H24F2N6O2 |
| Cas No. | 690257-74-0 |
| Smiles | [C@H]([C@@H](C(=O)N1CC(F)(F)CC1)N)(C(N(C)C)=O)C2=CC=C(C=C2)C3=CN4C(C=C3)=NC=N4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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