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GAS6 Protein, Human, Recombinant (hFc)
(Synonyms: growth arrest-specific protein 6, growth arrest-specific 6, GAS-6, Gas6, AXSFAXL receptor tyrosine kinase ligand, AXLLGAXL stimulatory factor, AXLLG) Copy Product InfoSynonyms: growth arrest-specific protein 6, growth arrest-specific 6, GAS-6, Gas6, AXSFAXL receptor tyrosine kinase ligand, AXLLGAXL stimulatory factor, AXLLG
Catalog No. TMPJ-00366 Copy Product Info
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $98 | - | In Stock | |
| 10 μg | $168 | - | In Stock | |
| 20 μg | $268 | 7-10 days | 7-10 days | |
| 50 μg | $511 | - | In Stock | |
| 100 μg | $793 | - | In Stock | |
| 200 μg | $1,290 | 7-10 days | 7-10 days | |
| 500 μg | $2,390 | 7-10 days | 7-10 days | |
| 1 mg | $3,580 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 95% as determined by reducing SDS-PAGE.
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1. Loaded Mouse AXL-His on HIS1K Biosensor, can bind Human GAS6-Fc with an affinity constant of 0.006 nM as determined in BLI assay. (Regularly tested)
2. Immobilized Human AXL-His at 5μg/ml (100 μl/well) can bind Human GAS6-Fc. The ED50 of Human GAS6-Fc is 55.16 ng/ml. (Regularly tested) |
| Description | GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | Q14393 |
| Amino Acid | Ala31-Ala678 |
| Construction | Ala31-Ala678 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | growth arrest-specific protein 6, growth arrest-specific 6, GAS-6, Gas6, AXSFAXL receptor tyrosine kinase ligand, AXLLGAXL stimulatory factor, AXLLG |
| Research Background |
| Molecular Weight | 110-120 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: GAS6 Protein, Human, Recombinant (hFc) chemical structure | GAS6 Protein, Human, Recombinant (hFc) molecular weight
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