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KWAR23
🥰Excellent
Catalog No. T77387
Alias KWAR 23
KWAR23 is a monoclonal antibody targeting SIRPα that blocks the interaction of SIRPα and SIRPγ with CD47, impairing chronic T-cell activation and IFN-γ secretion.
KWAR23
KWAR23
🥰Excellent
Catalog No. T77387Alias KWAR 23
KWAR23 is a monoclonal antibody targeting SIRPα that blocks the interaction of SIRPα and SIRPγ with CD47, impairing chronic T-cell activation and IFN-γ secretion.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $447 | - | In Stock | |
| 5 mg | $1,400 | - | In Stock | |
| 10 mg | $2,100 | - | In Stock | |
| 25 mg | $4,210 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | KWAR23 is a monoclonal antibody targeting SIRPα that blocks the interaction of SIRPα and SIRPγ with CD47, impairing chronic T-cell activation and IFN-γ secretion. |
| In vitro | The EC50 binding of KWAR23 to SIRPα on human CD14+ monocytes ranged from 0.267 to 0.385 μg/mL. In non-human primates, such as cynomolgus monkeys and rhesus monkeys, KWAR23 binds to CD14+ mononuclear cells with SIRP alpha and EC50 of 0.338 and 0.4, respectively. KWAR23 blocked the binding of CD47 to THP-1 cells, IC50 = 40.82 ng/mL. [1] |
| In vivo | KWAR23 showed potent antitumor activity in human SIRPA knock-in mouse models. [1] |
| Synonyms | KWAR 23 |
| Molecular Weight | 145.5 |
| Smiles | #N/A |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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