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KWAR23 (Synonyms: KWAR 23)
Catalog No. T77387 Copy Product Info
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KWAR23 is a monoclonal antibody targeting SIRPα that blocks the interaction of SIRPα and SIRPγ with CD47, impairing chronic T-cell activation and IFN-γ secretion.
KWAR23
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Catalog No. T77387
Synonyms KWAR 23
KWAR23 is a monoclonal antibody targeting SIRPα that blocks the interaction of SIRPα and SIRPγ with CD47, impairing chronic T-cell activation and IFN-γ secretion.
KWAR23
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $447 | Inquiry | Inquiry | |
| 5 mg | $1,400 | Inquiry | Inquiry | |
| 10 mg | $2,100 | Inquiry | Inquiry | |
| 25 mg | $4,210 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | KWAR23 is a monoclonal antibody targeting SIRPα that blocks the interaction of SIRPα and SIRPγ with CD47, impairing chronic T-cell activation and IFN-γ secretion. |
| In vitro | The EC50 binding of KWAR23 to SIRPα on human CD14+ monocytes ranged from 0.267 to 0.385 μg/mL. In non-human primates, such as cynomolgus monkeys and rhesus monkeys, KWAR23 binds to CD14+ mononuclear cells with SIRP alpha and EC50 of 0.338 and 0.4, respectively. KWAR23 blocked the binding of CD47 to THP-1 cells, IC50 = 40.82 ng/mL. [1] |
| In vivo | KWAR23 showed potent antitumor activity in human SIRPA knock-in mouse models. [1] |
| Synonyms | KWAR 23 |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Molecular Weight | 145.5 |
| Smiles | #N/A |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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