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RP-832c

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Catalog No. TP3944Cas No. 2375823-45-1

RP-832c is a synthetic analog of a host defense peptide (HDP) that targets the mannose receptor CD206 on M2-polarized macrophages with a Kd of 3.5 μM. Upon binding to CD206, RP-832c induces significant conformational changes in the receptor, activating signaling pathways that lead to rapid apoptosis of CD206-positive M2 macrophages and their repolarization to the M1 phenotype. Treatment with RP-832c significantly reduces CD206 gene expression in M2 macrophages and temporarily increases the expression of the M1 macrophage marker TNF-α. RP-832c is applicable for research on T-cell lymphomas (CTCL) and idiopathic pulmonary fibrosis (IPF).

RP-832c

RP-832c

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Catalog No. TP3944Cas No. 2375823-45-1
RP-832c is a synthetic analog of a host defense peptide (HDP) that targets the mannose receptor CD206 on M2-polarized macrophages with a Kd of 3.5 μM. Upon binding to CD206, RP-832c induces significant conformational changes in the receptor, activating signaling pathways that lead to rapid apoptosis of CD206-positive M2 macrophages and their repolarization to the M1 phenotype. Treatment with RP-832c significantly reduces CD206 gene expression in M2 macrophages and temporarily increases the expression of the M1 macrophage marker TNF-α. RP-832c is applicable for research on T-cell lymphomas (CTCL) and idiopathic pulmonary fibrosis (IPF).
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Product Introduction

Bioactivity
Description
RP-832c is a synthetic analog of a host defense peptide (HDP) that targets the mannose receptor CD206 on M2-polarized macrophages with a Kd of 3.5 μM. Upon binding to CD206, RP-832c induces significant conformational changes in the receptor, activating signaling pathways that lead to rapid apoptosis of CD206-positive M2 macrophages and their repolarization to the M1 phenotype. Treatment with RP-832c significantly reduces CD206 gene expression in M2 macrophages and temporarily increases the expression of the M1 macrophage marker TNF-α. RP-832c is applicable for research on T-cell lymphomas (CTCL) and idiopathic pulmonary fibrosis (IPF).
In vitro
RP-832c exhibits dose-dependent inhibition of M2-polarized bone marrow-derived macrophages (BMDM) within a concentration range of 0-100 μM, with an IC50 of 6.184 μM. It shows minimal cytotoxicity towards M1-polarized macrophages and no cytotoxicity to the human fetal lung fibroblast cell lines MRC5 and IMR9. At 10 μM for 24 hours, RP-832c significantly reduces CD206 expression in M2 macrophages and temporarily increases TNF-α expression.
In vivo
RP-832c, administered via intraperitoneal injection once daily for 10 days, inhibits tumor growth in the tumor microenvironment of cutaneous T-cell lymphoma by inducing the transition of immunosuppressive M2 macrophages to antitumor M1 macrophages. Additionally, RP-832c (5-10 mg/kg, subcutaneous injection, once daily for 21 days) demonstrates significant preventive and therapeutic effects in a mouse model of pulmonary fibrosis.
Chemical Properties
Molecular Weight1367.60
FormulaC68H94N20O11
Cas No.2375823-45-1
SmilesC([C@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC([C@H](CCCNC(=N)N)N)=O)=O)CCCCN)=O)=O)=O)=O)=O)CCCCN)=O)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C=5C=6C(NC5)=CC=CC6
SequenceArg-Trp-Lys-Phe-Gly-Gly-Phe-Lys-Trp-Arg
Sequence ShortRWKFGGFKWR
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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