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Vanzacaftor

Name: Vanzacaftor
Brand: TargetMol
SKU: T74417
Price: 196 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74417Cas No. 2374124-49-7

Alias VX-121, VX121

Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator designed to improve CFTR protein processing and trafficking to the cell surface. Vanzacaftor enhances CFTR functionality, restoring chloride transport, and serves as a critical research tool for the development of therapies targeting cystic fibrosis.

Vanzacaftor

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Purity: 99.14%

Catalog No. T74417Alias VX-121, VX121Cas No. 2374124-49-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$196	In Stock	In Stock
5 mg	$359	In Stock	In Stock
10 mg	$533	In Stock	In Stock
25 mg	$786	In Stock	In Stock
50 mg	$1,190	In Stock	In Stock
100 mg	$1,830	-	In Stock
1 mL x 10 mM (in DMSO)	$489	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.14%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator designed to improve CFTR protein processing and trafficking to the cell surface. Vanzacaftor enhances CFTR functionality, restoring chloride transport, and serves as a critical research tool for the development of therapies targeting cystic fibrosis.
In vitro	When the concentration of Vanzacaftor was 0-10 μM, it stimulated K⁺ secretion in Homo sapiens bronchial epithelial cells (HBEs) at low micromolar concentrations, with an EC₅₀ value of 4.4 μM for this effect being inhibited by Paxilline [2]. Treatment with 1 μM, 5 μM, and 10 μM Vanzacaftor significantly enhanced the αBKCa current in HEK cells, and this current could be blocked by Paxilline [2]. When 5 μM Vanzacaftor acted on hippocampal primary neurons, it reduced their action potential discharge frequency and altered neuronal excitability [2].
Synonyms	VX-121, VX121

Chemical Properties

Molecular Weight	617.76
Formula	C₃₂H₃₉N₇O₄S
Cas No.	2374124-49-7
Smiles	C(COC1=NN(C=C1)C=2N=C3N4C(C)(C)C[C@@](C4)(CCCN=C5NC(S(=O)(=O)NC(=O)C3=CC2)=CC=C5)[H])C6C7(C68CC8)CC7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (129.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6188 mL	8.0938 mL	16.1875 mL	80.9376 mL
5 mM	0.3238 mL	1.6188 mL	3.2375 mL	16.1875 mL
10 mM	0.1619 mL	0.8094 mL	1.6188 mL	8.0938 mL
20 mM	0.0809 mL	0.4047 mL	0.8094 mL	4.0469 mL
50 mM	0.0324 mL	0.1619 mL	0.3238 mL	1.6188 mL
100 mM	0.0162 mL	0.0809 mL	0.1619 mL	0.8094 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Vanzacaftor

Vanzacaftor

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