Salusin-α is an endogenous bioactive peptide known for its hemodynamic activity and its ability to promote cell proliferation. It stimulates the proliferation of resting vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate, although it is less potent than Salusin-β. Salusin-α holds potential application value in cardiovascular disease research.