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β-Tocopherol

Name: β-Tocopherol
Brand: TargetMol
SKU: T39142
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39142Cas No. 16698-35-4

β-Tocopherol, a vitamin E analog with antioxidant activity, inhibits tyrosinase activity and melanin production while suppressing PMA-induced human erythrocyte adhesion.

β-Tocopherol

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Purity: 99.93%

Catalog No. T39142Cas No. 16698-35-4

β-Tocopherol, a vitamin E analog with antioxidant activity, inhibits tyrosinase activity and melanin production while suppressing PMA-induced human erythrocyte adhesion.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$63	-	In Stock
5 mg	$152	-	In Stock
10 mg	$228	-	In Stock
25 mg	$389	-	In Stock
50 mg	$572	-	In Stock
100 mg	$813	-	In Stock
1 mL x 10 mM (in DMSO)	$166	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.93%

Appearance:Viscous

Color:Transparent

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

β-Tocopherol, a vitamin E analog with antioxidant activity, inhibits tyrosinase activity and melanin production while suppressing PMA-induced human erythrocyte adhesion.

In vitro

β-Tocopherol (250 µg/mL, 72 h) can downregulate the expression levels of tyrosinase and tyrosinase-related protein-2, thereby inhibiting melanin synthesis by 28%, with no significant cytotoxicity observed in B16 cells at this concentration [3].
β-Tocopherol (50 µM, 24 h) suppresses PMA-induced adhesion of human erythroleukemia cells and reduces the expression levels of integrin α4 and α5 on the cell surface [4].

Chemical Properties

Molecular Weight	416.68
Formula	C₂₈H₄₈O₂
Cas No.	16698-35-4
Smiles	CC1=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C)C(O)=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (191.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3999 mL	11.9996 mL	23.9992 mL	119.9962 mL
5 mM	0.4800 mL	2.3999 mL	4.7998 mL	23.9992 mL
10 mM	0.2400 mL	1.2000 mL	2.3999 mL	11.9996 mL
20 mM	0.1200 mL	0.6000 mL	1.2000 mL	5.9998 mL
50 mM	0.0480 mL	0.2400 mL	0.4800 mL	2.3999 mL
100 mM	0.0240 mL	0.1200 mL	0.2400 mL	1.2000 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc