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YM-254890

Name: YM-254890
Brand: TargetMol
SKU: T17273
Rating: 4.5 (1 reviews)

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Catalog No. T17273Cas No. 568580-02-9

Alias YM254890, YM 254890

YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling.

YM-254890

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Purity: 95%

Catalog No. T17273Alias YM254890, YM 254890Cas No. 568580-02-9

Pack Size	Price	Availability	Quantity
1 mg	$1,107	35 days

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Purity:95%

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Product Introduction

Bioactivity

Description	YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling.
Targets&IC50	HL-60 cells:> 10 μM, P2Y2-C6-15 cells:0.15 μM
In vitro	METHODS: The effects of YM-254890 on P2Y1 and P2Y12 signaling pathways were examined using C6-15 cells stably expressing human P2Y1 or P2Y12 receptors. RESULTS: 2MeSADP stimulation of P2Y1-C6-15 cells resulted in increased intracellular calcium mobilization. In this assay, YM-254890 inhibited the increase in [Ca2+]i (IC50: 0.031 μM). However, 40 μM of YM-254890 did not affect the 2MeSADP-induced inhibition of forskolin-stimulated adenylate cyclase activity in P2Y12-C6-15 cells [1].
Synonyms	YM254890, YM 254890

Chemical Properties

Molecular Weight	960.08
Formula	C₄₆H₆₉N₇O₁₅
Cas No.	568580-02-9
Smiles	CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (31.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0416 mL	5.2079 mL	10.4158 mL	52.0790 mL
5 mM	0.2083 mL	1.0416 mL	2.0832 mL	10.4158 mL
10 mM	0.1042 mL	0.5208 mL	1.0416 mL	5.2079 mL
20 mM	0.0521 mL	0.2604 mL	0.5208 mL	2.6039 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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