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YM-254890

Name: YM-254890
Brand: TargetMol
SKU: T17273
Rating: 4.5 (1 reviews)

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Catalog No. T17273Cas No. 568580-02-9

Alias YM254890, YM 254890

YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling.

YM-254890

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Purity: 95%

Catalog No. T17273Alias YM254890, YM 254890Cas No. 568580-02-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$1,107	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling.
Targets&IC50	HL-60 cells:> 10 μM, P2Y2-C6-15 cells:0.15 μM
In vitro	METHODS: The effects of YM-254890 on P2Y1 and P2Y12 signaling pathways were examined using C6-15 cells stably expressing human P2Y1 or P2Y12 receptors. RESULTS: 2MeSADP stimulation of P2Y1-C6-15 cells resulted in increased intracellular calcium mobilization. In this assay, YM-254890 inhibited the increase in [Ca2+]i (IC50: 0.031 μM). However, 40 μM of YM-254890 did not affect the 2MeSADP-induced inhibition of forskolin-stimulated adenylate cyclase activity in P2Y12-C6-15 cells [1].
Synonyms	YM254890, YM 254890

Chemical Properties

Molecular Weight	960.08
Formula	C₄₆H₆₉N₇O₁₅
Cas No.	568580-02-9
Smiles	CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (31.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.5 mg/mL (1.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0416 mL	5.2079 mL	10.4158 mL	52.0790 mL
5 mM	0.2083 mL	1.0416 mL	2.0832 mL	10.4158 mL
10 mM	0.1042 mL	0.5208 mL	1.0416 mL	5.2079 mL
20 mM	0.0521 mL	0.2604 mL	0.5208 mL	2.6039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc