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N-Palmitoyl Glycine

Name: N-Palmitoyl Glycine
Brand: TargetMol
SKU: T37219
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Palmitoylglycine) Copy Product Info

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Synonyms: Palmitoylglycine

Catalog No. T37219 Copy Product Info

Purity: 98%

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N-Palmitoyl Glycine is an endogenous lipid that modulates calcium influx and nitric oxide (NO) production in sensory neurons. It is associated with an increased risk of Brugada syndrome (BrS), interacts with BrS-related proteins, and shows moderate binding affinity to molecules including DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA.

Cas No. 2441-41-0

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Pack Size	Price	USA Stock	Global Stock
10 mg	$30	-	In Stock
25 mg	$42	-	In Stock
50 mg	$68	-	In Stock
100 mg	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	N-Palmitoyl Glycine is an endogenous lipid that modulates calcium influx and nitric oxide (NO) production in sensory neurons. It is associated with an increased risk of Brugada syndrome (BrS), interacts with BrS-related proteins, and shows moderate binding affinity to molecules including DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA.
In vitro	Methods: The effect of N-Palmitoyl Glycine on calcium ion influx was examined in adult dorsal root ganglion (DRG) cells and DRG-like cell lines. Its effects on nitric oxide (NO) production and calcium-sensitive nitric oxide synthase (NOS) were investigated in F-11 cells. Results: 1.N-Palmitoyl Glycine induced transient calcium ion influx in adult DRG cells and DRG-like cell lines [3]. 2.N-Palmitoyl Glycine promoted nitric oxide (NO) production via calcium-sensitive nitric oxide synthase (NOS) expressed in F-11 cells [3].
In vivo	Methods: The effect of N-Palmitoyl Glycine on the electrical activity of pain-sensitive neurons in the rat dorsal horn was observed. Results: N-Palmitoyl Glycine potently inhibited heat-evoked firing of pain-sensitive neurons in the rat dorsal horn [3].
Synonyms	Palmitoylglycine

Chemical Properties

Molecular Weight	313.48
Formula	C₁₈H₃₅NO₃
Cas No.	2441-41-0
Smiles	O=C(O)CNC(=O)CCCCCCCCCCCCCCC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (12.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1900 mL	15.9500 mL	31.9000 mL	159.4998 mL
5 mM	0.6380 mL	3.1900 mL	6.3800 mL	31.9000 mL
10 mM	0.3190 mL	1.5950 mL	3.1900 mL	15.9500 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

N-Palmitoyl GlycineNPalmitoyl GlycineN Palmitoyl Glycine

Related Tags: N-Palmitoyl Glycine chemical structure | N-Palmitoyl Glycine in vivo | N-Palmitoyl Glycine in vitro | N-Palmitoyl Glycine formula | N-Palmitoyl Glycine molecular weight