Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 65.00 | |
5 mg | In stock | $ 126.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 361.00 | |
50 mg | In stock | $ 549.00 | |
100 mg | In stock | $ 789.00 | |
500 mg | In stock | $ 1,630.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 161.00 |
Description | BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages. |
In vitro |
BTB09089 (0-18 μM; 30 min) significantly increases the accumulation of cAMP in HEK293 cells transiently expressing hTDAG8 and mTDAG8, but does not exhibit a notable increase in control HEK293 cells. BTB09089 does not enhance the accumulation of cAMP in HEK293 cells expressing hGPR4 or the accumulation of inositol phosphates in HEK293 cells expressing hOGR1.[1]
BTB09089 (0-18 μM; 30 min) significantly enhances the accumulation of cAMP in a dose-dependent manner at pH 7.0-7.9, but not at pH 6.5.[1] BTB09089 (1-5 μM; 20 h) dose-dependently inhibits the production of IL-2 in WT mouse splenocytes, but does not inhibit IL-2 production in TDAG8 KO mice and does not affect cell viability.[1] BTB09089 (1-5 μM; 18 h) inhibits the production of TNF-α and IL-6 stimulated by LPS, while enhancing the production of IL-10 in peritoneal exudate cells (TG-PEC) induced by LPS stimulation with sulfated ester.[1] |
In vivo | BTB09089 (5-20 μM, 8 μL; i.c.v.; administered 6 hours prior to MCAO) reduces cerebral ischemia-reperfusion injury in rats.[2] |
Synonyms | GPR65 agonist (BTB09089) |
Molecular Weight | 387.31 |
Formula | C14H12Cl2N4OS2 |
CAS No. | 245728-44-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.87 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BTB09089 245728-44-3 DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein DNA GPR BTB 09089 GPR65 agonist GPR65 agonist (BTB09089) BTB-09089 inhibitor inhibit