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Cu(II)GTSM
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Catalog No. T40792Cas No. 68341-14-0
Alias Cu-GTSM
Cu(II)GTSM is a cell permeable copper complex that significantly inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau, and is able to reverse cognitive deficits in Alzheimer's disease mice.
Cu(II)GTSM
😃Good
Purity: 99.21%
Catalog No. T40792Alias Cu-GTSMCas No. 68341-14-0
Cu(II)GTSM is a cell permeable copper complex that significantly inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau, and is able to reverse cognitive deficits in Alzheimer's disease mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | - | In Stock | |
| 5 mg | $68 | - | In Stock | |
| 10 mg | $118 | - | In Stock | |
| 25 mg | $269 | - | In Stock | |
| 50 mg | $458 | - | In Stock | |
| 100 mg | $780 | - | In Stock | |
| 200 mg | $1,060 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $73 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.21%
Appearance:Solid
Color:Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cu(II)GTSM is a cell permeable copper complex that significantly inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau, and is able to reverse cognitive deficits in Alzheimer's disease mice. |
| In vitro | Methods: PC12 cells treated with NGF for 48 hours were treated with Cu(II)GTSM (25, 50, 100 nM, 18 hours) and then examined. Results: MTT assay Results showed a small but significant loss of MTT reduction at 25 and 50 nMd of Cu(II)GTSM treatment; LDH assay showed that there was actually a small but significant reduction in LDH release when using 100 nM Cu(II)GTSM. [3] |
| In vivo | Treatment of AD mice with Cu(II)GTSM (10 mg/kg) can reduce the level of brain Aβ trimers in AD mice, restore the cognitive ability of AD mice to the expected level of healthy, cognitively normal mice, and reverse the cognitive deficits of APP/PS1 transgenic AD mice. [2] |
| Synonyms | Cu-GTSM |
| Molecular Weight | 293.86 |
| Formula | C6H10CuN6S2 |
| Cas No. | 68341-14-0 |
| Smiles | N1=C([S-][Cu+2]23[S-]C(=N[N]3=CC=[N]12)NC)NC |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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