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AGS-16C3F
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Catalog No. T9901A-963
Alias AGS-16M8F
AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3 (also known as CD203c). This product consists of a humanized IgG1 monoclonal antibody against ENPP3 conjugated to the microtubule inhibitor monomethyl auristatin F (MMAF) via a non-cleavable linker. AGS-16C3F functions by specifically binding to ENPP3 on the surface of tumor cells, undergoing internalization, and releasing MMAF intracellularly to induce cell cycle arrest and apoptosis. It exhibits potent anti-tumor and anti-proliferative activity in ENPP3-expressing metastatic renal cell carcinoma (mRCC) and systemic mastocytosis.
AGS-16C3F
AGS-16C3F
Copy Product Info😃Good
Catalog No. T9901A-963Alias AGS-16M8F
AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3 (also known as CD203c). This product consists of a humanized IgG1 monoclonal antibody against ENPP3 conjugated to the microtubule inhibitor monomethyl auristatin F (MMAF) via a non-cleavable linker. AGS-16C3F functions by specifically binding to ENPP3 on the surface of tumor cells, undergoing internalization, and releasing MMAF intracellularly to induce cell cycle arrest and apoptosis. It exhibits potent anti-tumor and anti-proliferative activity in ENPP3-expressing metastatic renal cell carcinoma (mRCC) and systemic mastocytosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3 (also known as CD203c). This product consists of a humanized IgG1 monoclonal antibody against ENPP3 conjugated to the microtubule inhibitor monomethyl auristatin F (MMAF) via a non-cleavable linker. AGS-16C3F functions by specifically binding to ENPP3 on the surface of tumor cells, undergoing internalization, and releasing MMAF intracellularly to induce cell cycle arrest and apoptosis. It exhibits potent anti-tumor and anti-proliferative activity in ENPP3-expressing metastatic renal cell carcinoma (mRCC) and systemic mastocytosis. |
| In vitro | AGS-16C3F inhibits proliferation of CD203c-high ROSA cells (96 h IC50: 1.1-2.73 nM), HMC-1.1 (IC50: 109.9 nM), and HMC-1.2 cells (IC50: 146.5 nM). It induces dose-dependent apoptosis (0.5-100 nM, 96-120 h) by disrupting microtubule dynamics [2]. |
| In vivo | In pharmacological studies using NOD-SCID gamma mouse models xenografted with ROSA cells, systemic administration of AGS-16C3F (1 or 4 mg/kg; i.v.; once every 4 days for 4 doses) significantly reduces tumor burden. The treatment leads to a marked decrease in tumor cells within the peripheral blood, bone marrow, and spleen, while significantly prolonging survival without evidence of overt toxicity in complex physiological environments [2]. |
| Synonyms | AGS-16M8F |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Uniprot ID | |
| Target | ENPP3/CD203c |
| Isotype | IgG1 |
| Storage | store at low temperature,keep away from direct sunlight | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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