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BBT

Name: BBT
Brand: TargetMol
SKU: T78066
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78066Cas No. 445000-45-3

BBT has anti-hyperglycemic activity, acting through cAMP/PKA and the persistent L-type voltage-dependent Ca2+ channels/CaMK2 pathways to protect β-cells from cytokine or streptozotocin (STZ)-induced cell death and restore β-cell function, used in studies of diabetes.

BBT

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Purity: 99.02%

Catalog No. T78066Cas No. 445000-45-3

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.02%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BBT has anti-hyperglycemic activity, acting through cAMP/PKA and the persistent L-type voltage-dependent Ca2+ channels/CaMK2 pathways to protect β-cells from cytokine or streptozotocin (STZ)-induced cell death and restore β-cell function, used in studies of diabetes.
In vitro	BBT stimulates insulin secretion in a glucose-dependent manner. BBT effectively reversed β cell death induced by treatment with STZ (0.4 mM) or cytokines (10 ng/ml TNF-α and 5 ng/ml IL1B) in a dose-dependent manner. BBT can reverse STZ or cytokine-induced GSIS defects. [1]
In vivo	BBT (50 mg/kg/day intravenously for 4 weeks) improved glucose homeostasis in STZ/ HFD-induced type 2 diabetes mice. [1]

Chemical Properties

Molecular Weight	386.26
Formula	C₁₈H₁₂BrNO₂S
Cas No.	445000-45-3
Smiles	O=C(NC=1C=CC=CC1C(=O)C=2C=CC=CC2)C=3SC(Br)=CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (258.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5889 mL	12.9446 mL	25.8893 mL	129.4465 mL
5 mM	0.5178 mL	2.5889 mL	5.1779 mL	25.8893 mL
10 mM	0.2589 mL	1.2945 mL	2.5889 mL	12.9446 mL
20 mM	0.1294 mL	0.6472 mL	1.2945 mL	6.4723 mL
50 mM	0.0518 mL	0.2589 mL	0.5178 mL	2.5889 mL
100 mM	0.0259 mL	0.1294 mL	0.2589 mL	1.2945 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc