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BBT

🥰Excellent
Catalog No. T78066Cas No. 445000-45-3

BBT has anti-hyperglycemic activity, acting through cAMP/PKA and the persistent L-type voltage-dependent Ca2+ channels/CaMK2 pathways to protect β-cells from cytokine or streptozotocin (STZ)-induced cell death and restore β-cell function, used in studies of diabetes.

BBT

BBT

🥰Excellent
Purity: 99.02%
Catalog No. T78066Cas No. 445000-45-3
BBT has anti-hyperglycemic activity, acting through cAMP/PKA and the persistent L-type voltage-dependent Ca2+ channels/CaMK2 pathways to protect β-cells from cytokine or streptozotocin (STZ)-induced cell death and restore β-cell function, used in studies of diabetes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$33In StockIn Stock
25 mg$68In StockIn Stock
50 mg$108In StockIn Stock
100 mg$172In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.02%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
BBT has anti-hyperglycemic activity, acting through cAMP/PKA and the persistent L-type voltage-dependent Ca2+ channels/CaMK2 pathways to protect β-cells from cytokine or streptozotocin (STZ)-induced cell death and restore β-cell function, used in studies of diabetes.
In vitro
BBT stimulates insulin secretion in a glucose-dependent manner.
BBT effectively reversed β cell death induced by treatment with STZ (0.4 mM) or cytokines (10 ng/ml TNF-α and 5 ng/ml IL1B) in a dose-dependent manner.
BBT can reverse STZ or cytokine-induced GSIS defects. [1]
In vivo
BBT (50 mg/kg/day intravenously for 4 weeks) improved glucose homeostasis in STZ/ HFD-induced type 2 diabetes mice. [1]
Chemical Properties
Molecular Weight386.26
FormulaC18H12BrNO2S
Cas No.445000-45-3
SmilesO=C(NC=1C=CC=CC1C(=O)C=2C=CC=CC2)C=3SC(Br)=CC3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (258.89 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5889 mL12.9446 mL25.8893 mL129.4465 mL
5 mM0.5178 mL2.5889 mL5.1779 mL25.8893 mL
10 mM0.2589 mL1.2945 mL2.5889 mL12.9446 mL
20 mM0.1294 mL0.6472 mL1.2945 mL6.4723 mL
50 mM0.0518 mL0.2589 mL0.5178 mL2.5889 mL
100 mM0.0259 mL0.1294 mL0.2589 mL1.2945 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

CalciumChannelCalcium Channel
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