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AMG-193

Name: AMG-193
Brand: TargetMol
SKU: T85645
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T85645Cas No. 2790567-82-5

Alias AMG193

AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.

AMG-193

🥰Excellent

Purity: 99.52%

Catalog No. T85645Alias AMG193Cas No. 2790567-82-5

AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$347	In Stock	In Stock
50 mg	$562	In Stock	In Stock
100 mg	$893	-	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.
Targets&IC50	HCT116 cells:0.13 μM
In vitro	AMG-193 is a PRMT5 inhibitor. AMG-193 significantly inhibited the proliferation of HCT116 cells with an IC50 value of 0.13 μM. [1]
Synonyms	AMG193

Chemical Properties

Molecular Weight	444.41
Formula	C₂₂H₁₉F₃N₄O₃
Cas No.	2790567-82-5
Smiles	C(=O)(C=1C=C2C3=C(C(N)=NC2=CN1)COC3)N4[C@H](COCC4)C5=CC=C(C(F)(F)F)C=C5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (180.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (11.25 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2502 mL	11.2509 mL	22.5017 mL	112.5087 mL
5 mM	0.4500 mL	2.2502 mL	4.5003 mL	22.5017 mL
10 mM	0.2250 mL	1.1251 mL	2.2502 mL	11.2509 mL
20 mM	0.1125 mL	0.5625 mL	1.1251 mL	5.6254 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2502 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1251 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc