Methyl cellulose (Viscosity:4000mPa.s) is a methyl ester derivative of cellulose exhibiting thermogel properties. It is commonly employed as a thickener, emulsifier, and biomaterial, widely utilised in life science research and experimentation.

Methods: Methyl cellulose (Viscosity:4000mPa.s) (0.5%, twice weekly for 6 weeks) was administered to CF-1 mice via intraperitoneal injection and oral routes to evaluate its effects on systemic histological lesions in mice, particularly its impact on the phenotype of preclinical disease models.
Results: Repeated intraperitoneal injection of low-concentration Methyl cellulose (0.5%) induced systemic histological lesions in mice but did not affect the preclinical phenotype of the CKM model. Despite extensive pathological changes, the behavior and seizure stability of the mice remained unaffected. Mice administered Methyl cellulose orally did not exhibit the aforementioned lesions. [1]