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Pegamotecan

Catalog No. T24610   CAS 581079-18-7
Synonyms: Prothecan, PEG-camptothecin, PEG-beta-CPT

Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung and pancreatic cancers.

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Pegamotecan Chemical Structure
Pegamotecan, CAS 581079-18-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 390.00
5 mg In stock $ 928.00
10 mg In stock $ 1,260.00
25 mg In stock $ 1,880.00
50 mg In stock $ 2,530.00
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Purity: 97.96%
ee: 100%
Purity: 97.24%
ee: 100%
Purity: 96.52%
ee: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung and pancreatic cancers.
Synonyms Prothecan, PEG-camptothecin, PEG-beta-CPT
Molecular Weight 980.984
Formula C52H48N6O14
CAS No. 581079-18-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (16.99 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Chuang CH, et al. Development of pH-Sensitive Cationic PEGylated Solid Lipid Nanoparticles for Selective Cancer-Targeted Therapy. J Biomed Nanotechnol. 2017 Feb;13(2):192-03. 2. Omar R, et al. Amphiphilic star PEG-Camptothecin conjugates for intracellular targeting. J Control Release. 2017 Jul 10;257:76-83. 3. Song ZL, et al. Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2690-3. 4. Scott LC, et al. A phase II study of pegylated-camptothecin (pegamotecan) in the treatment of locally advanced and metastatic gastric and gastro-oesophageal junction adenocarcinoma. Cancer Chemother Pharmacol. 2009 Jan;63(2):363-70.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library

Related Products

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Idarubicin hydrochloride Berberine Rubitecan Enoxacin hydrate Isosteviol XR-11576 HCl Voreloxin Irinotecan Hydrochloride

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Keywords

Pegamotecan 581079-18-7 DNA Damage/DNA Repair Topoisomerase Prothecan PEG-camptothecin PEG-β-CPT PEG-beta-CPT PEG-b-CPT inhibitor inhibit

 

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