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CBPD-268
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Catalog No. T209630
CBPD-268 is an effective orally active CBP/p300 PROTAC degrader, with a DC50 value of ≤ 0.03 nM. It induces degradation of CBP/p300 and inhibits cell growth, exhibiting antitumor activity. Additionally, CBPD-268 shows potential for research in AR-positive prostate cancer.
CBPD-268
CBPD-268
Copy Product Info😃Good
Catalog No. T209630
CBPD-268 is an effective orally active CBP/p300 PROTAC degrader, with a DC50 value of ≤ 0.03 nM. It induces degradation of CBP/p300 and inhibits cell growth, exhibiting antitumor activity. Additionally, CBPD-268 shows potential for research in AR-positive prostate cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CBPD-268 is an effective orally active CBP/p300 PROTAC degrader, with a DC50 value of ≤ 0.03 nM. It induces degradation of CBP/p300 and inhibits cell growth, exhibiting antitumor activity. Additionally, CBPD-268 shows potential for research in AR-positive prostate cancer. |
| In vitro | CBPD-268 demonstrates high degradation efficiency on CBP and p300 proteins in 22Rv1 cells with DC50 values of 0.01 and 0.03 nM, respectively, after 4 hours. The compound achieves degradation by binding to CBP/p300 and CRBN proteins. Additionally, CBPD-268 (0-1000 nM; 4 days) inhibits cell growth with IC50 values of 3.7, 10.3, and 4.6 nM in 22Rv1, LNCaP, and VCaP cells, respectively. |
| In vivo | CBPD-268, administered orally at doses of 0.3, 1, 3, to 10, and 30 mg/kg as a single dose, induces degradation of CBP and p300 proteins in tumor tissues. When given at 1 mg/kg twice a week or 3 mg/kg weekly for 4 weeks, CBPD-268 shows antitumor activity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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