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GSN Protein, Human, Recombinant (mFc)
(Synonyms: GSN, Gelsolin, Brevin, AGEL, ADF, Actin-depolymerizing factor) Copy Product InfoSynonyms: GSN, Gelsolin, Brevin, AGEL, ADF, Actin-depolymerizing factor
Catalog No. TMPJ-00790 Copy Product Info
Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Gelsolin is composed of six of these domains, termed G1-6. Some reaseraches show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. The difference in the expression levels of cytoplasmic and plasma gelsolin suggests that these two different forms of gelsolin may play different roles after cardiac injury. Plasma gelsolin, as an important component of the EASS, may have evolved to rapidly clear actin filaments from the circulation that are released by injured or dead cells.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $98 | 7-10 days | 7-10 days | |
| 10 μg | $160 | 7-10 days | 7-10 days | |
| 20 μg | $255 | 7-10 days | 7-10 days | |
| 50 μg | $479 | 7-10 days | 7-10 days | |
| 100 μg | $778 | 7-10 days | 7-10 days | |
| 200 μg | $1,260 | 7-10 days | 7-10 days | |
| 500 μg | $2,420 | 7-10 days | 7-10 days | |
| 1 mg | $3,630 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 90% as determined by reducing SDS-PAGE.
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Gelsolin is composed of six of these domains, termed G1-6. Some reaseraches show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. The difference in the expression levels of cytoplasmic and plasma gelsolin suggests that these two different forms of gelsolin may play different roles after cardiac injury. Plasma gelsolin, as an important component of the EASS, may have evolved to rapidly clear actin filaments from the circulation that are released by injured or dead cells. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-mFc |
| Accession Number | P06396 |
| Amino Acid | Ala28-Ala782 |
| Construction | Ala28-Ala782 |
| Protein Purity | Greater than 90% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 1 mM DTT, 5% Trehalose, 0.1% Triton X-100, pH 8.0. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | GSN, Gelsolin, Brevin, AGEL, ADF, Actin-depolymerizing factor |
| Research Background |
| Molecular Weight | 115-125 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: GSN Protein, Human, Recombinant (mFc) chemical structure | GSN Protein, Human, Recombinant (mFc) molecular weight
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