IL-15 & IL-15RA Protein, Human, Recombinant (hFc)

Catalog No. TMPY-06020 Copy Product Info

IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1.

IL-15 & IL-15RA Protein, Human, Recombinant (hFc)

Catalog No. TMPY-06020

Copy Product Info

IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$85	7-10 days	7-10 days
10 μg	$146	7-10 days	7-10 days
20 μg	$242	7-10 days	7-10 days
50 μg	$477	7-10 days	7-10 days
100 μg	$929	7-10 days	7-10 days
200 μg	$1,390	7-10 days	7-10 days
500 μg	$2,930	7-10 days	7-10 days
1 mg	$5,930	7-10 days	7-10 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells (QC tested).
Description	IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	NP_002180.1&NP_000576.1
Construction	A DNA sequence encoding the human IL15RA (NP_002180.1) (Ile31-Asp96) linked with the human IL15 (NP_000576.1, with mutation Asn 120 Asp) (Asn49-Ser162) by a peptide linker was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ile 31
Protein Purity	> 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC.
Molecular Weight	47.9 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mMTris, 100 mMNacl, 5%trehalose, 0.05%chaps, pH8.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	IL-15 and IL-15 receptor alpha (IL-15Rα) play a significant role in multiple aspects of T cell biology. Interleukin (IL)-15 is essential for natural killer (NK), NKT and memory (m) CD8+ T cell development and function, and is currently under investigation as an immunotherapeutic agent for the treatment of cancer. Recently, the creation of IL-15 superagonist by complexing IL-15 and its high affinity receptor alpha (IL-15 Rα) in solution, inspired by the natural trans-presentation of IL-15, advances the potential of IL-15-based tumor immunotherapy. Gene therapy using engineered cells co-expressing IL-15/IL-15 Rα complex for cancer treatment is also emerging.

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