Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Tat-NTS peptide

😃Good
Catalog No. TP3540

Tat-NTS peptide is a cell-penetrating peptide with neuroprotective properties. It specifically inhibits the nuclear translocation of ANXA1, reducing neuronal apoptosis (apoptosis) in ischemic areas. Additionally, Tat-NTS peptide can decrease the volume of cerebral ischemic infarction, making it useful for research on ischemic stroke.

Tat-NTS peptide
Other Forms of Tat-NTS peptide:
Tat-NTS Peptide TFAT83727
Backorder
View details

Tat-NTS peptide

😃Good
Catalog No. TP3540
Tat-NTS peptide is a cell-penetrating peptide with neuroprotective properties. It specifically inhibits the nuclear translocation of ANXA1, reducing neuronal apoptosis (apoptosis) in ischemic areas. Additionally, Tat-NTS peptide can decrease the volume of cerebral ischemic infarction, making it useful for research on ischemic stroke.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mgInquiryInquiryInquiry
50 mgInquiryInquiryInquiry
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
Tat-NTS peptide is a cell-penetrating peptide with neuroprotective properties. It specifically inhibits the nuclear translocation of ANXA1, reducing neuronal apoptosis (apoptosis) in ischemic areas. Additionally, Tat-NTS peptide can decrease the volume of cerebral ischemic infarction, making it useful for research on ischemic stroke.
In vitro
Tat-NTS peptide (20 μM) inhibits the nuclear translocation of ANXA1 in neuronal cells without affecting the nuclear migration of other proteins. Additionally, it prevents the interaction between ANXA1 and p53, reducing neuronal apoptosis induced by oxygen-glucose deprivation/reperfusion (OGD/R), thereby offering neuroprotective effects. The peptide significantly improves the viability of neuronal cells following OGD/R.
In vivo
Tat-NTS peptide (0.5-10 mg/kg; ICV; single dose) reduces the interaction between ANXA1 and importin β in C57BL/6 mice with middle cerebral artery occlusion (MCAO) and inhibits the nuclear translocation of ANXA1 in vivo. It exhibits neuroprotective effects against neuronal apoptosis following ischemic injury in mice with brain ischemia.
Chemical Properties
FormulaC125H212N54O24
SequenceTyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
Sequence ShortYGRKKRRQRRRRSFPHLRRVF
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Tat-NTS peptide | purchase Tat-NTS peptide | Tat-NTS peptide cost | order Tat-NTS peptide | Tat-NTS peptide in vivo | Tat-NTS peptide in vitro | Tat-NTS peptide formula
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.