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VB124

Catalog No. T60165 CAS 2230186-18-0

VB124 is an orally active, potent, and selective inhibitor of MCT4. VB124 can specifically inhibit lactate efflux with IC 50 s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism [1].

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VB124, CAS 2230186-18-0

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	VB124 is an orally active, potent, and selective inhibitor of MCT4. VB124 can specifically inhibit lactate efflux with IC 50 s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism [1].
In vitro	VB124 (10 μM) inhibits the cell proliferation of MDA-MB-231 cells, and the cell proliferation rate is less than 50% [1]. VB124 is more selective to MCT4 than MCT1, exhibiting very little MCT1 inhibitory activity (lactate export IC 50 =24 μM) in MCT1-expressing BT20 cells [1].
In vivo	VB124 (30 mg/kg; p.o.; daily for 28 days) reduces isoproterenol-induced cardiac hypertrophy in mice [1]. VB124 (30 mg/kg; twice per day for 180 days) has no effect on the body, heart, liver, or lung weight of mice, suggesting no overt toxicities [1]. Animal Model: 12 weeks old C57BL/6 mice [1] Dosage: 30 mg/kg Administration: Oral gavage; daily for 28 days (dissolved in 0.5% methylcellulose and 0.1% Tween-20) Result: Prevented cardiac hypertrophy in mice.

Molecular Weight	426.9
Formula	C23H23ClN2O4
CAS No.	2230186-18-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90mg/mL (210.8mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cluntun AA, et.al. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab. 2021 Mar 2;33(3):629-648.e10.

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α-Cyano-4-hydroxycinnamic acid MCT1-IN-3 AZD0095 VB124 7ACC1 BAY-8002 AZD3965 7ACC2

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VB124 2230186-18-0 Membrane transporter/Ion channel Monocarboxylate transporter Inhibitor inhibitor inhibit

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