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VB124

Catalog No. T60165 CAS 2230186-18-0

VB124 is an orally active, potent, and selective MCT4 inhibitor, demonstrating specificity in hindering lactate efflux, with IC50 values of 8.6 nM and 19 nM for lactate import and export, respectively, in MDA-MB-231 cells. Its high selectivity for MCT4 over MCT1 positions VB124 as a promising agent for researching cardiac hypertrophy, heart failure, and metabolic disorders [1].

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VB124, CAS 2230186-18-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 297.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 997.00
50 mg	In stock	$ 1,590.00
100 mg	In stock	$ 2,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 336.00

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Purity: 99.21%

Biological Description

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Description	VB124 is an orally active, potent, and selective MCT4 inhibitor, demonstrating specificity in hindering lactate efflux, with IC50 values of 8.6 nM and 19 nM for lactate import and export, respectively, in MDA-MB-231 cells. Its high selectivity for MCT4 over MCT1 positions VB124 as a promising agent for researching cardiac hypertrophy, heart failure, and metabolic disorders [1].
In vitro	VB124 (10 μM) inhibits the cell proliferation of MDA-MB-231 cells, and the cell proliferation rate is less than 50% [1]. VB124 is more selective to MCT4 than MCT1, exhibiting very little MCT1 inhibitory activity (lactate export IC 50 =24 μM) in MCT1-expressing BT20 cells [1].
In vivo	VB124, administered orally at a dosage of 30 mg/kg daily for 28 days, effectively mitigates isoproterenol-induced cardiac hypertrophy in 12-week-old C57BL/6 mice, as evidenced by a study [1]. The same compound at the same dosage, when given twice daily for 180 days, demonstrated no significant impact on the body, heart, liver, or lung weight in mice, indicating a lack of overt toxicities [1]. The administration involved oral gavage of VB124 dissolved in 0.5% methylcellulose and 0.1% Tween-20, underscoring its efficacy in preventing cardiac enlargement without apparent toxicity.

Molecular Weight	426.89
Formula	C23H23ClN2O4
CAS No.	2230186-18-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (210.8 mM), Sonication is recommended.

References and Literature

1. Cluntun AA, et.al. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab. 2021 Mar 2;33(3):629-648.e10.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

7ACC1 Niflumic acid Lactate transportor 1 AR-C155858 AZD0095 BAY-8002 MCT1-IN-3 7ACC2

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VB124 2230186-18-0 Membrane transporter/Ion channel Monocarboxylate transporter VB-124 VB 124 inhibitor inhibit

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