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YX968
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Catalog No. T88929Cas No. 2742732-92-7
YX968 is an effective selective dual degrader of HDAC3/8, with DC50 values of 1.7 and 6.8 nM respectively. It exerts its anti-tumor activity by inducing cell apoptosis (apoptosis).
YX968
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Catalog No. T88929Cas No. 2742732-92-7
YX968 is an effective selective dual degrader of HDAC3/8, with DC50 values of 1.7 and 6.8 nM respectively. It exerts its anti-tumor activity by inducing cell apoptosis (apoptosis).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | YX968 is an effective selective dual degrader of HDAC3/8, with DC50 values of 1.7 and 6.8 nM respectively. It exerts its anti-tumor activity by inducing cell apoptosis (apoptosis). |
| Targets&IC50 | HDAC3:1.7 nM (DC50), HDAC8:6.8 nM (DC50) |
| In vitro | YX968 (1 μM, 24 h) induces apoptosis by blocking cell cycle at the G1 phase. |
| Molecular Weight | 831.12 |
| Formula | C45H66N8O5S |
| Cas No. | 2742732-92-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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