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U-83836E

Name: U-83836E
Brand: TargetMol
SKU: T23480
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23480Cas No. 137018-55-4

U-83836E (lazaroid ) has neuroprotective activity and anti-tumor activity, inhibits glioma cell proliferation, inhibits tumor necrosis factor and reverses endotoxin-induced shock.

U-83836E

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🥰Excellent

Purity: 99.676%

Catalog No. T23480Cas No. 137018-55-4

U-83836E (lazaroid ) has neuroprotective activity and anti-tumor activity, inhibits glioma cell proliferation, inhibits tumor necrosis factor and reverses endotoxin-induced shock.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$117	In Stock	In Stock
50 mg	$172	In Stock	In Stock
100 mg	$255	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.676%

ee:100%

Appearance:Solid

Color:Yellow

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COA LCMS CSFC HNMR IC

Product Introduction

U-83836E AI Summary

U-83836E exhibits antimycobacterial activity against Mycobacterium smegmatis. It shows inhibition of bacterial growth in nitrogen-limited, carbon-limited, and Luria-Bertani broth media. The growth inhibition was assessed using spectrophotometry and GFP-based fluorescence assays. The Minimum Inhibitory Concentration (MIC) for this compound is determined to be 50000.0 nM in most assays, and the half-maximal inhibitory concentration (IC50) is above 50000.0 nM in certain growth conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

U-83836E (lazaroid ) has neuroprotective activity and anti-tumor activity, inhibits glioma cell proliferation, inhibits tumor necrosis factor and reverses endotoxin-induced shock.

Chemical Properties

Molecular Weight	593.63
Formula	C₃₀H₄₆Cl₂N₆O₂
Cas No.	137018-55-4
Smiles	CC1=C2C(O[C@](C)(CC2)CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)=C(C(C)=C1O)C.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (101.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6846 mL	8.4228 mL	16.8455 mL	84.2275 mL
5 mM	0.3369 mL	1.6846 mL	3.3691 mL	16.8455 mL
10 mM	0.1685 mL	0.8423 mL	1.6846 mL	8.4228 mL
20 mM	0.0842 mL	0.4211 mL	0.8423 mL	4.2114 mL
50 mM	0.0337 mL	0.1685 mL	0.3369 mL	1.6846 mL
100 mM	0.0168 mL	0.0842 mL	0.1685 mL	0.8423 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc