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Isoallolithocholic acid
🥰Excellent
Catalog No. T36522Cas No. 2276-93-9
Alias Alloisolithocholic Acid, AILCA, 3β-Hydroxy-5α-cholanic acid
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.
Isoallolithocholic acid
🥰Excellent
Purity: 99.31%
Catalog No. T36522Alias Alloisolithocholic Acid, AILCA, 3β-Hydroxy-5α-cholanic acidCas No. 2276-93-9
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $65 | - | In Stock | |
| 5 mg | $175 | - | In Stock | |
| 10 mg | $278 | - | In Stock | |
| 25 mg | $486 | - | In Stock | |
| 50 mg | $778 | - | In Stock | |
| 100 mg | $1,245 | - | In Stock | |
| 200 mg | $1,988 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $212 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.31%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis. |
| In vitro | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) reduces Th17 cell differentiation by approximately 50% without affecting RORγt expression. It does not impact Th1 or Th2 cell differentiation, and its regulatory effect on Tregs is cell-type specific. Isoallolithocholic acid-dependent enhancement of FoxP3 expression requires mitoROS.[1] |
| In vivo | Isoallolithocholic acid (0.03%; in the diet; 7 days; Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice) was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to the control diet in combination with 0.3% (w/w) 3-oxo-lithocholic acid (3-oxoLCA). Reduced the number of CD45.1+ T effector cells. Enhancing Treg cells in B6 mice.[1] |
| Synonyms | Alloisolithocholic Acid, AILCA, 3β-Hydroxy-5α-cholanic acid |
| Molecular Weight | 376.57 |
| Formula | C24H40O3 |
| Cas No. | 2276-93-9 |
| Smiles | [H][C@@]12CC[C@H]([C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12C |
| Relative Density. | 1.073 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF: 1 mg/mL (2.66 mM), Sonication is recommended. DMF:PBS (pH 7.2) (1:3): 0.25 mg/mL (0.66 mM), Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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