store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a T-cell modulator, a bile acid metabolite with anti-inflammatory activity that is associated with human immune homeostasis.
Description | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a T-cell modulator, a bile acid metabolite with anti-inflammatory activity that is associated with human immune homeostasis. |
In vitro |
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) reduces Th17 cell differentiation by approximately 50% without affecting RORγt expression.[1] Isoallolithocholic acid does not affect the differentiation of T cells into Th1 or Th2 cells, and the regulatory effect of Isoallolithocholic acid on Tregs is cell-type specific.[1] Isoallolithocholic acid-dependent enhancement of FoxP3 expression requires mitoROS.[1] |
In vivo | Isoallolithocholic acid (0.03%; in the diet; 7 days; Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice) was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to the control diet in combination with 0.3% (w/w) 3-oxo-lithocholic acid (3-oxoLCA). Reduced the number of CD45.1+ T effector cells. Enhancing Treg cells in B6 mice.[1] |
Synonyms | Alloisolithocholic Acid, AILCA, 3β-Hydroxy-5α-cholanic acid |
Molecular Weight | 376.57 |
Formula | C24H40O3 |
CAS No. | 2276-93-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 1 mg/mL
DMF:PBS (pH 7.2) (1:3): 0.25 mg/mL
You can also refer to dose conversion for different animals. More
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Isoallolithocholic acid 2276-93-9 Others Alloisolithocholic Acid 3beta-Hydroxy-5alpha-cholanic acid AILCA 3β-Hydroxy-5α-cholanic acid 3b-Hydroxy-5a-cholanic acid inhibitor inhibit